Tyloxapol - reagent grade, high purity , CAS No.25301-02-4

1 Citations
Item Number
T100874
Grouped product items
SKUSizeAvailabilityPrice Qty
T100874-1g
1g
In stock
$14.90
T100874-5g
5g
In stock
$54.90
T100874-25g
25g
In stock
$246.90

Basic Description

Synonymscomponent of Alevaire | Triton WR-1339 | DTXSID30179950 | Formaldehyde,1,3,3-tetra methylbutyl)phenol | Superinone | Alevaire | AB01563398_01 | Q7860340 | formaldehyde; oxirane; 4-(1,1,3,3-tetramethylbutyl)phenol | AKOS026749862 | Superiuone | WLN: /QR DX
Specifications & Purityreagent grade
Shipped InNormal
GradeReagent Grade
Product Description

A nonionic liquid polymer of the alkyl aryl polyether alcohol type. Used as a surfactant.

Names and Identifiers

IUPAC Name formaldehyde;oxirane;4-(2,4,4-trimethylpentan-2-yl)phenol
INCHI InChI=1S/C14H22O.C2H4O.CH2O/c1-13(2,3)10-14(4,5)11-6-8-12(15)9-7-11;1-2-3-1;1-2/h6-9,15H,10H2,1-5H3;1-2H2;1H2
InChi Key MDYZKJNTKZIUSK-UHFFFAOYSA-N
Canonical SMILES CC(C)(C)CC(C)(C)C1=CC=C(C=C1)O.C=O.C1CO1
Isomeric SMILES CC(C)(C)CC(C)(C)C1=CC=C(C=C1)O.C=O.C1CO1
WGK Germany 2
RTECS SM9750000
PubChem CID 71388
Molecular Weight 280.4

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

9 results found

Lot NumberCertificate TypeDateItem
J2229603Certificate of AnalysisAug 16, 2024 T100874
J2229604Certificate of AnalysisAug 16, 2024 T100874
J2229605Certificate of AnalysisAug 16, 2024 T100874
G2402534Certificate of AnalysisApr 12, 2024 T100874
K2103691Certificate of AnalysisAug 22, 2023 T100874
H2325101Certificate of AnalysisAug 10, 2023 T100874
H2325102Certificate of AnalysisAug 10, 2023 T100874
H2325103Certificate of AnalysisAug 10, 2023 T100874
H2325104Certificate of AnalysisAug 10, 2023 T100874

Chemical and Physical Properties

Flash Point(°C)113°C

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H361:Suspected of damaging fertility or the unborn child

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P203:Obtain, read and follow all safety instructions before use.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P318:if exposed or concerned, get medical advice.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 2
RTECS SM9750000

Related Documents

Citations of This Product

1. Qiuhe Wang, Zheng Wu, Feifei Wang, Hua Zhang, Li Gan.  (2023)  Tacrolimus-Loaded Cationic Nanoemulsion In-Situ Gel System: In-Vitro Characterization and Performance in a Dry-Eye Rabbit Model.  JOURNAL OF PHARMACEUTICAL SCIENCES,  112  (2790).  [PMID:37453530]

References

1. Jung-hua Steven Kuo,Ming-shiou Jan,Hsuan Wen Chiu.  (2006-06-17)  Cytotoxic properties of tyloxapol..  Pharmaceutical research,  23  ((7)): (1509-1516).  [PMID:16779702]
2. Chi-Liang Eric Yen,Mei-Leng Cheong,Carrie Grueter,Ping Zhou,Junya Moriwaki,Jinny S Wong,Brian Hubbard,Stephen Marmor,Robert V Farese.  (2009-03-17)  Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding..  Nature medicine,  15  ((4)): (442-446).  [PMID:19287392]
3. Juliana Trevisan da Rocha,Adriane Sperança,Cristina Wayne Nogueira,Gilson Zeni.  (2009-12-05)  Hypolipidaemic activity of orally administered diphenyl diselenide in Triton WR-1339-induced hyperlipidaemia in mice..  The Journal of pharmacy and pharmacology,  61  ((12)): (1673-1679).  [PMID:19958591]
4. Bonggi Lee,Angela M Fast,Jiabin Zhu,Ji-Xin Cheng,Kimberly K Buhman.  (2010-02-12)  Intestine-specific expression of acyl CoA:diacylglycerol acyltransferase 1 reverses resistance to diet-induced hepatic steatosis and obesity in Dgat1-/- mice..  Journal of lipid research,  51  ((7)): (1770-1780).  [PMID:20147738]
5. Arun Sethi,Akriti Bhatia,Sanjay Srivastava,Geetika Bhatia,M M Khan,A K Khanna,J K Saxena.  (2010-02-20)  Pregnane glycoside from Hemidesmus indicus as a potential anti-oxidant and anti-dyslipidemic agent..  Natural product research,  24  ((15)): (1371-1378).  [PMID:20169502]
6. Adejuwon Adewale Adeneye,Olufunmilayo Olaide Adeyemi,Esther Oluwatoyin Agbaje.  (2010-05-18)  Anti-obesity and antihyperlipidaemic effect of Hunteria umbellata seed extract in experimental hyperlipidaemia..  Journal of ethnopharmacology,  130  ((2)): (307-314).  [PMID:20471465]
7. Ghassan Shattat,Tariq Al-Qirim,Kamal Sweidan,Moyad Shahwan,Waseem El-Huneidi,Yusuf Al-Hiari.  (2010-07-02)  The hypolipidemic activity of novel benzofuran-2-carboxamide derivatives in Triton WR-1339-induced hyperlipidemic rats: a comparison with bezafibrate..  Journal of enzyme inhibition and medicinal chemistry,  25  ((6)): (751-755).  [PMID:20590406]
8. Moyad Shahwan,Ghassan Shattat,Tariq Al-Qirim,Ghassan Abu Sheikha,Yusuf Al-Hiari,Waseem El-Huneidi,Anan Jarab,Manal Al-Najdawi.  (2010-07-27)  Synthesis and pharmacological evaluation of novel substituted and unsubstituted N-(benzoylphenyl)-1H-indole-2-carboxamides as potent antihypertriglyceridemic agents..  Zeitschrift fur Naturforschung. C, Journal of biosciences,  65  ((5-6)): (309-316).  [PMID:20653231]
9. David P Macfarlane,Xiantong Zou,Ruth Andrew,Nicholas M Morton,Dawn E W Livingstone,Rebecca L Aucott,Moffat J Nyirenda,John P Iredale,Brian R Walker.  (2010-12-02)  Metabolic pathways promoting intrahepatic fatty acid accumulation in methionine and choline deficiency: implications for the pathogenesis of steatohepatitis..  American journal of physiology. Endocrinology and metabolism,  300  ((2)): (E402-E409).  [PMID:21119028]
10. Tiago R Figueira,Aníbal E Vercesi,Helena C F Oliveira.  (2010-12-29)  Lack of plasma albumin impairs intravascular lipolysis and explains the associated free fatty acids deficiency and hypertriglyceridemia..  Lipids in health and disease,  (146-146).  [PMID:21187011]
11. Ghassan Shattat,Rania Al-Qirim,Yusuf Al-Hiari,Ghassan Abu Sheikha,Tariq Al-Qirim,Waseem El-Huneidi,Moyad Shahwan.  (2011-02-19)  Synthesis and anti-hyperlipidemic evaluation of N‑(benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide derivatives in Triton WR-1339-induced hyperlipidemic rats..  Molecules (Basel, Switzerland),  15  ((9)): (5840-5849).  [PMID:21330955]
12. Neha Mittal,Sankar Nath Sanyal.  (2011-04-05)  Surfactant blocks lipopolysaccharide signaling by inhibiting both NFκB and PARP activation in experimental ARDS..  Molecular and cellular biochemistry,  354  ((1-2)): (113-122).  [PMID:21461608]
13. Panneerselvam Vijayaraj,Kannan Muthukumar,Jayaraja Sabarirajan,Vasanthi Nachiappan.  (2011-08-20)  Antihyperlipidemic activity of Cassia auriculata flowers in triton WR 1339 induced hyperlipidemic rats..  Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie,  65  ((1-2)): (135-141).  [PMID:21852078]
14. Yusuf Al-Hiari,Ghassan Shattat,Tariq Al-Qirim,Waseem El-Huneidi,Ghassan Abu Sheikha,Suhair Hikmat.  (2011-10-01)  Antihyperlipidemic properties of novel N-(benzoylphenyl)-5-substituted-1H-indole-2-carboxamides in Triton WR-1339-induced hyperlipidemic rats..  Molecules (Basel, Switzerland),  16  ((10)): (8292-8304).  [PMID:21959300]
15. Sadaf Matinkhoo,Karlene H Lynch,Jonathan J Dennis,Warren H Finlay,Reinhard Vehring.  (2011-10-25)  Spray-dried respirable powders containing bacteriophages for the treatment of pulmonary infections..  Journal of pharmaceutical sciences,  100  ((12)): (5197-5205).  [PMID:22020816]
16. Wei Li,Hao-yan Jia,Xin-hua He,Wei-guo Shi,Bo-hua Zhong.  (2011-11-17)  Novel phenoxyalkylcarboxylic acid derivatives as hypolipidaemic agents..  Journal of enzyme inhibition and medicinal chemistry,  27  ((2)): (311-318).  [PMID:22085137]
17. Tariq Al-Qirim,Ghassan Shattat,Kamal Sweidan,Waseem El-Huneidi,Ghassan Abu Sheikha,Reema Abu Khalaf,Suhair Hikmat.  (2012-01-24)  In vivo antihyperlipidemic activity of a new series of N-(benzoylphenyl) and N-(acetylphenyl)-1-benzofuran-2-carboxamides in rats..  Archiv der Pharmazie,  345  ((5)): (401-406).  [PMID:22266816]
18. Maciej Gawlik,Małgorzata B Gawlik,Jerzy Brandys.  (2012-03-06)  The impact of Triton WR-1339 induced hyperlipidemia on the effects of benzo(a)pyrene or guaiacol on α- and γ-tocopherol pools and selected markers of pro-/antioxidative balance in rat plasma and erythrocytes..  Environmental toxicology and pharmacology,  33  ((3)): (386-393).  [PMID:22387351]
19. Vincent Frochot,Malik Alqub,Anne-Laure Cattin,Véronique Carrière,Anne Houllier,Floriane Baraille,Laurence Barbot,Susan Saint-Just,Agnès Ribeiro,Michel Lacasa,Philippe Cardot,Jean Chambaz,Monique Rousset,Jean-Marc Lacorte.  (2012-03-31)  The transcription factor HNF-4α: a key factor of the intestinal uptake of fatty acids in mouse..  American journal of physiology. Gastrointestinal and liver physiology,  302  ((11)): (G1253-G1263).  [PMID:22461026]
20. S K Mehta,Neha Jindal.  (2012-09-27)  Formulation of Tyloxapol niosomes for encapsulation, stabilization and dissolution of anti-tubercular drugs..  Colloids and surfaces. B, Biointerfaces,  101  (434-441).  [PMID:23010052]
21. Koneni V Sashidhara,Gopala Reddy Palnati,Ranga Prasad Dodda,Ravi Sonkar,A K Khanna,Gitika Bhatia.  (2012-10-20)  Discovery of amide based fibrates as possible antidyslipidemic and antioxidant agents..  European journal of medicinal chemistry,  57  (302-310).  [PMID:23078966]
22. Roberto Martínez-Beamonte,María A Navarro,Sergio Acin,Natalia Guillén,Cristina Barranquero,Carmen Arnal,Joaquín Surra,Jesus Osada.  (2013-02-06)  Postprandial changes in high density lipoproteins in rats subjected to gavage administration of virgin olive oil..  PloS one,  ((1)): (e55231-e55231).  [PMID:23383120]
23. S K Mehta,Neha Jindal.  (2013-06-12)  Mixed micelles of Lecithin-Tyloxapol as pharmaceutical nanocarriers for anti-tubercular drug delivery..  Colloids and surfaces. B, Biointerfaces,  110  (419-425).  [PMID:23751420]
24. Yu-Han Hung,Alicia L Carreiro,Kimberly K Buhman.  (2017-03-03)  Dgat1 and Dgat2 regulate enterocyte triacylglycerol distribution and alter proteins associated with cytoplasmic lipid droplets in response to dietary fat..  Biochimica et biophysica acta,  1862  ((6)): (600-614).  [PMID:28249764]
25. Austin Potts,Aki Uchida,Stanislaw Deja,Eric D Berglund,Blanka Kucejova,Joao A Duarte,Xiaorong Fu,Jeffrey D Browning,Mark A Magnuson,Shawn C Burgess.  (2018-04-11)  Cytosolic phosphoenolpyruvate carboxykinase as a cataplerotic pathway in the small intestine..  American journal of physiology. Gastrointestinal and liver physiology,  315  ((2)): (G249-G258).  [PMID:29631378]
26. DeDe Kwun-Wai Man,Tokuwa Kanno,Giorgia Manzo,Brian D Robertson,Jenny K W Lam,A James Mason.  (2018-07-20)  Rifampin- or Capreomycin-Induced Remodeling of the Mycobacterium smegmatis Mycolic Acid Layer Is Mitigated in Synergistic Combinations with Cationic Antimicrobial Peptides..  mSphere,  ((4)):   [PMID:30021876]
27. Zhenhua Wu,Fan Yang,Shan Jiang,Xiaoyu Sun,Jialin Xu.  (2018-08-08)  Induction of Liver Steatosis in BAP31-Deficient Mice Burdened with Tunicamycin-Induced Endoplasmic Reticulum Stress..  International journal of molecular sciences,  19  ((8)):   [PMID:30081561]
28. Martina Theresa Hackl,Clemens Fürnsinn,Christina Maria Schuh,Martin Krssak,Fabrizia Carli,Sara Guerra,Angelika Freudenthaler,Sabina Baumgartner-Parzer,Thomas H Helbich,Anton Luger,Maximilian Zeyda,Amalia Gastaldelli,Christoph Buettner,Thomas Scherer.  (2019-06-22)  Brain leptin reduces liver lipids by increasing hepatic triglyceride secretion and lowering lipogenesis..  Nature communications,  10  ((1)): (2717-2717).  [PMID:31222048]
29. Meng Yang,Qingli Liu,Tongling Huang,Wenjuan Tan,Linbing Qu,Tianke Chen,Haobo Pan,Ling Chen,Jinsong Liu,Chi-Wai Wong,William W Lu,Min Guan.  (2020-10-13)  Dysfunction of estrogen-related receptor alpha-dependent hepatic VLDL secretion contributes to sex disparity in NAFLD/NASH development..  Theranostics,  10  ((24)): (10874-10891).  [PMID:33042259]
30. Yanyong Xu,Yuanyuan Li,Kavita Jadhav,Xiaoli Pan,Yingdong Zhu,Shuwei Hu,Shaoru Chen,Liuying Chen,Yong Tang,Helen H Wang,Ling Yang,David Q-H Wang,Liya Yin,Yanqiao Zhang.  (2021-01-20)  Hepatocyte ATF3 protects against atherosclerosis by regulating HDL and bile acid metabolism..  Nature metabolism,  ((1)): (59-74).  [PMID:33462514]
31. Jung-Hua Steven Kuo,Yi-Lin Lin,Jo-Wen Tseng.  (2008-03-14)  Interactions between U-937 human macrophages and tyloxapol..  Colloids and surfaces. B, Biointerfaces,  64  ((2)): (208-215).  [PMID:18337068]
32. Vishnu Kumar,Pradyumn Singh,Ramesh Chander,Farzana Mahdi,Sushma Singh,Ranjana Singh,Ashok Kumar Khanna,Jitendra Kumar Saxena,Abbas Ali Mahdi,Vinod Kumar Singh.  (2010-04-07)  Hypolipidemic activity of Hibiscus rosa sinensis root in rats..  Indian journal of biochemistry & biophysics,  46  ((6)): (507-510).  [PMID:20361715]
33. Jianheng Zheng,Ge Zhang,Yang Lu,Fang Fang,Jiake He,Ning Li,Amer Talbi,Ying Zhang,Yue Tang,Jiabi Zhu,Xijing Chen.  (2010-12-09)  Effect of pulmonary surfactant and phospholipid hexadecanol tyloxapol on recombinant human-insulin absorption from intratracheally administered dry powders in diabetic rats..  Chemical & pharmaceutical bulletin,  58  ((12)): (1612-1616).  [PMID:21139264]
34. Tatyana A Korolenko,Marina S Cherkanova,Fedor V Tuzikov,Thomas P Johnston,Natalia A Tuzikova,Viktoriya M Loginova,Vassilij I Kaledin.  (2011-05-19)  Influence of atorvastatin on fractional and subfractional composition of serum lipoproteins and MMP activity in mice with Triton WR 1339-induced lipaemia..  The Journal of pharmacy and pharmacology,  63  ((6)): (833-839).  [PMID:21585382]
35. M Saravanan,P Pandikumar,N Prakash Babu,S Ignacimuthu.  (2011-05-20)  Antihyperlipidemic activity of Ichnocarpus frutescens in triton WR-1339-induced and high-fat diet animals..  Pharmaceutical biology,  49  ((10)): (1074-1081).  [PMID:21591834]
36. Christudas Sunil,Savarimuthu Ignacimuthu,Chidambaram Kumarappan.  (2011-06-18)  Hypolipidemic activity of Symplocos cochinchinensis S. Moore leaves in hyperlipidemic rats..  Journal of natural medicines,  66  ((1)): (32-38).  [PMID:21681640]
37. Aki Uchida,Mary C Whitsitt,Trisha Eustaquio,Mikhail N Slipchenko,James F Leary,Ji-Xin Cheng,Kimberly K Buhman.  (2012-03-01)  Reduced triglyceride secretion in response to an acute dietary fat challenge in obese compared to lean mice..  Frontiers in physiology,  (26-26).  [PMID:22375122]
38. Jianheng Zheng,Yi Zheng,Jiayin Chen,Fang Fang,Jiake He,Ning Li,Yue Tang,Jiabi Zhu,Xijing Chen.  (2012-07-07)  Enhanced pulmonary absorption of recombinant human insulin by pulmonary surfactant and phospholipid hexadecanol tyloxapol through Calu-3 monolayers..  Die Pharmazie,  67  ((5)): (448-451).  [PMID:22764580]
39. Alessandra dos Santos Danziger Silvério,Rosemary Gualberto Fonseca Alvarenga Pereira,Adriene Ribeiro Lima,Fernanda Borges de Araújo Paula,Maria Rita Rodrigues,Lineu Baldissera,Stella Maris da Silveira Duarte.  (2013-06-20)  The effects of the decaffeination of coffee samples on platelet aggregation in hyperlipidemic rats..  Plant foods for human nutrition (Dordrecht, Netherlands),  68  ((3)): (268-273).  [PMID:23780748]
40. Nancy Cheng,Melissa A Porter,Lloyd W Frick,Yvonne Nguyen,Jennifer D Hayden,Ellen F Young,Miriam S Braunstein,Emily A Hull-Ryde,William P Janzen.  (2014-05-03)  Filtration improves the performance of a high-throughput screen for anti-mycobacterial compounds..  PloS one,  ((5)): (e96348-e96348).  [PMID:24788852]
41. Minyi Zhang,Meng Yang,Na Wang,Qingli Liu,Binxu Wang,Tongling Huang,Yan Tong,Yanlin Ming,Chi-Wai Wong,Jinsong Liu,Dongsheng Yao,Min Guan.  (2020-05-19)  Andrographolide modulates HNF4α activity imparting on hepatic metabolism..  Molecular and cellular endocrinology,  513  (110867-110867).  [PMID:32422400]
42. Fatma S Coskun,Shashikant Srivastava,Prithvi Raj,Igor Dozmorov,Serkan Belkaya,Smriti Mehra,Nadia A Golden,Allison N Bucsan,Moti L Chapagain,Edward K Wakeland,Deepak Kaushal,Tawanda Gumbo,Nicolai S C van Oers.  (2020-08-28)  sncRNA-1 Is a Small Noncoding RNA Produced by Mycobacterium tuberculosis in Infected Cells That Positively Regulates Genes Coupled to Oleic Acid Biosynthesis..  Frontiers in microbiology,  11  (1631-1631).  [PMID:32849337]
43. Qiuhe Wang, Zheng Wu, Feifei Wang, Hua Zhang, Li Gan.  (2023)  Tacrolimus-Loaded Cationic Nanoemulsion In-Situ Gel System: In-Vitro Characterization and Performance in a Dry-Eye Rabbit Model.  JOURNAL OF PHARMACEUTICAL SCIENCES,  112  (2790).  [PMID:37453530]

Solution Calculators