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Tyrosine kinase-IN-1 - 98%, high purity , CAS No.705946-27-6, Inhibitor of AXL receptor tyrosine kinase;Inhibitor of fibroblast growth factor receptor 1;Inhibitor of fms related receptor tyrosine kinase 1;Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of fms related receptor tyrosine kinase 4;Inhibito

  • Moligand™
  • ≥98%
Item Number
T412126
Grouped product items
SKUSizeAvailabilityPrice Qty
T412126-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$69.90
T412126-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$109.90
T412126-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$219.90
T412126-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$349.90
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View related series
AXL receptor tyrosine kinase Inhibitor fibroblast growth factor receptor 1 Inhibitor fms related receptor tyrosine kinase 1 Inhibitor fms related receptor tyrosine kinase 3 Inhibitor fms related receptor tyrosine kinase 4 Inhibitor kinase insert domain receptor Inhibitor KIT proto-oncogene，receptor tyrosine kinase Inhibitor macrophage stimulating 1 receptor Inhibitor MET proto-oncogene，receptor tyrosine kinase Inhibitor platelet derived growth factor receptor alpha Inhibitor platelet derived growth factor receptor beta Inhibitor TEK receptor tyrosine kinase Inhibitor

Basic Description

SynonymsTyrosine kinase-IN-1|705946-27-6|XL999|XL-999|6I7PLF6N8L|XL 999 [WHO-DD]|(3Z)-5-[(1-ethylpiperidin-4-yl)amino]-3-[(3-fluorophenyl)-(5-methyl-1H-imidazol-2-yl)methylidene]-1H-indol-2-one|(Z)-5-((1-ethylpiperidin-4-yl)amino)-3-((3-fluorophenyl)(5-methyl-1H-
Specifications & Purity98%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of AXL receptor tyrosine kinase;Inhibitor of fibroblast growth factor receptor 1;Inhibitor of fms related receptor tyrosine kinase 1;Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of fms related receptor tyrosine kinase 4;Inhibito
Product Description

Information

Tyrosine kinase-IN-1 (XL999) is a multi-targeted tyrosine kinase inhibitor with IC50 of 4 nM, 20 nM, 4 nM, 2 nM for KDR, Flt-1, FGFR1 and PDGFRα, respectively.

Associated Targets

MST1R Tchem Macrophage-stimulating protein receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FLT4 Tclin Vascular endothelial growth factor receptor 3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FLT3 Tclin Receptor-type tyrosine-protein kinase FLT3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FGFR1 Tclin Fibroblast growth factor receptor 1 3 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MET Tclin Hepatocyte growth factor receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TEK Tclin Angiopoietin-1 receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PDGFRA Tclin Platelet-derived growth factor receptor alpha 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PDGFRB Tclin Platelet-derived growth factor receptor beta 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FLT1 Tclin Vascular endothelial growth factor receptor 1 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KDR Tclin Vascular endothelial growth factor receptor 2 3 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AXL Tchem Tyrosine-protein kinase receptor UFO 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KIT Tclin Mast/stem cell growth factor receptor Kit 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (3Z)-5-[(1-ethylpiperidin-4-yl)amino]-3-[(3-fluorophenyl)-(5-methyl-1H-imidazol-2-yl)methylidene]-1H-indol-2-one
INCHI InChI=1S/C26H28FN5O/c1-3-32-11-9-19(10-12-32)30-20-7-8-22-21(14-20)24(26(33)31-22)23(25-28-15-16(2)29-25)17-5-4-6-18(27)13-17/h4-8,13-15,19,30H,3,9-12H2,1-2H3,(H,28,29)(H,31,33)/b24-23-
InChi Key DMQYDVBIPXAAJA-VHXPQNKSSA-N
Canonical SMILES CCN1CCC(CC1)NC2=CC3=C(C=C2)NC(=O)C3=C(C4=CC(=CC=C4)F)C5=NC=C(N5)C
Isomeric SMILES CCN1CCC(CC1)NC2=CC\3=C(C=C2)NC(=O)/C3=C(/C4=CC(=CC=C4)F)\C5=NC=C(N5)C
Alternate CAS 921206-68-0,705946-27-6
PubChem CID 10433653
Molecular Weight 445.53

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8 results found

Lot NumberCertificate TypeDateItem
B2427351Certificate of AnalysisJan 20, 2024 T412126
B2427352Certificate of AnalysisJan 20, 2024 T412126
B2427359Certificate of AnalysisJan 20, 2024 T412126
B2427360Certificate of AnalysisJan 20, 2024 T412126
B2427361Certificate of AnalysisJan 20, 2024 T412126
B2427366Certificate of AnalysisJan 20, 2024 T412126
B2427367Certificate of AnalysisJan 20, 2024 T412126
B2427368Certificate of AnalysisJan 20, 2024 T412126

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