133550-35-3|Tyrphostin B48|AG 494|AG-494|Tyrphostin AG 494|Tyrphostin AG-494|(E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylacrylamide|139087-53-9|alpha-Cyano-(3,4-dihydroxy)-N-phenylcinnamide|(E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-PHENYL-2-PROPENAMIDE|CHEMBL
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
Potent, selective EGF receptor tyrosine kinase inhibitor (IC 50 = 0.7 μM). Selective over ErbB2, PDGF receptor tyrosine kinase and insulin receptor (IC 50 values are 42, 6 and 100 μM respectively).
Storage Temp
Store at -80°C
Shipped In
Ice chest + Ice pads
Product Description
AG-494 (Tyrphostin AG 494) is a potent and selective EGFR tyrosine kinase inhibitor (IC50=0.7 μM). AG-494 inhibits the autophosphorylation of EGFR, ErbB2, HER1-2 and PDGF-R with IC50s 1.1, 39, 45 and 6 μM, respectively. AG-494 blocks Cdk2 activation and inhibits EGF-dependent DNA synthesis
