pAb; Rabbit anti Human UBQLN2 Antibody; WB, IHC; Unconjugated
| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab133349-10μl | 10μl | In stock | $69.90 | |
| Ab133349-50μl | 50μl | In stock | $199.90 | |
| Ab133349-100μl | 100μl | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $299.90 | |
| Ab133349-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,599.90 |
pAb; Rabbit anti Human UBQLN2 Antibody; WB, IHC; Unconjugated
| Product Name | UBQLN2 Antibody - Primary antibody, specific to UBQLN2, Rabbit IgG |
|---|---|
| Synonyms | Chap1 | DSK2 homolog | hPLIC-2 | PLIC-2 | Protein linking IAP with cytoskeleton 2 | Ubiquitin-like product Chap1/Dsk2 | bA431N15.1 antibody | CHAP 1 antibody | CHAP1 antibody | CHAP1/DSK2 antibody | Dsk 2 antibody | Dsk2 antibody | DSK2 homolog antibody | |
| Specifications & Purity | ExactAb™, Validated, Carrier Free, 0.5 mg/mL |
| Host species | Rabbit |
| Specificity | UBQLN2 |
| Immunogen | A KLH conjugated synthetic peptide from the N-terminal region of human Dsk2 (AA 20-50). |
| Positive Control | WB: HeLa, MCF7, A431, A549, NIH/3T3 and C6 cell lysates. IHC: Human cancer and lung carcinoma tissues |
| Conjugation | Unconjugated |
| Grade | Carrier Free, ExactAb™, Validated |
| Product Description | Rabbit anti Human UBQLN2 Antibody, Polyclonal, could be used for WB, IHC and so on. |
| Isotype | Rabbit IgG |
|---|---|
| SDS-PAGE | 150 kDa |
| Purification Method | Saturated ammonium sulfate precipitation |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Temp | Store at -20°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at 4°C short term (1-2 weeks). Store at -20°C long term (24months). Upon delivery aliquot. Avoid freeze/thaw cycle. |
UBQLN2 Antibody (Ab133349) - Western Blot
All lanes: UBQLN2 Antibody (Ab133349) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 66 kDa
Observed band size: 66 kDa
Exposure time: 7.8 s
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Application | Dilution info |
|---|---|
| IHC | 1/100-1/500 |
| WB |
1/1000
|
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ24F0303484 | Certificate of Analysis | Mar 21, 2024 | Ab133349 |
| ZJ24F0303483 | Certificate of Analysis | Mar 21, 2024 | Ab133349 |
| 1. Sharon Gauci,Andreas O Helbig,Monique Slijper,Jeroen Krijgsveld,Albert J R Heck,Shabaz Mohammed. (2009-05-06) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.. Analytical chemistry, 81 ((11)): (4493-4501). [PMID:19413330] |
| 2. Ueki, N N and 5 more authors.. (1998) Selection system for genes encoding nuclear-targeted proteins.. Nature biotechnology, [PMID:9853615] |
| 3. Kaye, F J FJ and 7 more authors.. (2000) A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch.. FEBS letters, (11): [PMID:10675567] |
| 4. Kleijnen, M F MF and 7 more authors.. (2000) The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome.. Molecular cell, [PMID:10983987] |
| 5. Walters, Kylie J KJ, Kleijnen, Maurits F MF, Goh, Amanda M AM, Wagner, Gerhard G and Howley, Peter M PM.. (2002) Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a.. Biochemistry, (12): [PMID:11827521] |
| 6. Ross, Mark T MT and 281 more authors.. (2005) The DNA sequence of the human X chromosome.. Nature, (17): [PMID:15772651] |
| 7. Ford, Diana L DL and Monteiro, Mervyn J MJ.. (2006) Dimerization of ubiquilin is dependent upon the central region of the protein: evidence that the monomer, but not the dimer, is involved in binding presenilins.. The Biochemical journal, (1): [PMID:16813565] |
| 8. Kang, Yang Y, Zhang, Naixia N, Koepp, Deanna M DM and Walters, Kylie J KJ.. (2007) Ubiquitin receptor proteins hHR23a and hPLIC2 interact.. Journal of molecular biology, (26): [PMID:17098253] |
| 9. N'Diaye, Elsa-Noah EN and 6 more authors.. (2008) The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis.. Molecular biology of the cell, [PMID:18199683] |
| 10. Kim, Tae-Yeon TY, Kim, Eunmin E, Yoon, Sungjoo Kim SK and Yoon, Jong-Bok JB.. (2008) Herp enhances ER-associated protein degradation by recruiting ubiquilins.. Biochemical and biophysical research communications, (2): [PMID:18307982] |
| 11. N'Diaye, Elsa-Noah EN and 5 more authors.. (2009) PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation.. EMBO reports, [PMID:19148225] |
| 12. Rothenberg, Cara C and 9 more authors.. (2010) Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy.. Human molecular genetics, (15): [PMID:20529957] |
| 13. Deng, Han-Xiang HX and 22 more authors.. (2011) Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia.. Nature, (21): [PMID:21857683] |
| 14. Daoud, Hussein H and 9 more authors.. (2012) UBQLN2 mutations are rare in French and French-Canadian amyotrophic lateral sclerosis.. Neurobiology of aging, [PMID:22560112] |
| 15. Williams, Kelly L KL and 7 more authors.. (2012) UBQLN2/ubiquilin 2 mutation and pathology in familial amyotrophic lateral sclerosis.. Neurobiology of aging, [PMID:22717235] |
| 16. Van Damme, Petra P and 15 more authors.. (2012) N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.. Proceedings of the National Academy of Sciences of the United States of America, (31): [PMID:22814378] |
| 17. Synofzik, Matthis M and 9 more authors.. (2012) Screening in ALS and FTD patients reveals 3 novel UBQLN2 mutations outside the PXX domain and a pure FTD phenotype.. Neurobiology of aging, [PMID:22892309] |
| 18. Lee, Dong Yun DY, Arnott, David D and Brown, Eric J EJ.. (2013) Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery.. EMBO reports, [PMID:23459205] |
| 19. Cassel, Joel A JA and Reitz, Allen B AB.. (2013) Ubiquilin-2 (UBQLN2) binds with high affinity to the C-terminal region of TDP-43 and modulates TDP-43 levels in H4 cells: characterization of inhibition by nucleic acids and 4-aminoquinolines.. Biochimica et biophysica acta, [PMID:23541532] |
| 20. Xia, Yuxing Y and 5 more authors.. (2014) Pathogenic mutation of UBQLN2 impairs its interaction with UBXD8 and disrupts endoplasmic reticulum-associated protein degradation.. Journal of neurochemistry, [PMID:24215460] |
| 21. Farg, Manal A MA and 11 more authors.. (2014) C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking.. Human molecular genetics, (1): [PMID:24549040] |
| 22. Zhang, Katharine Y KY, Yang, Shu S, Warraich, Sadaf T ST and Blair, Ian P IP.. (2014) Ubiquilin 2: a component of the ubiquitin-proteasome system with an emerging role in neurodegeneration.. The international journal of biochemistry & cell biology, [PMID:24589709] |
| 23. and Marín, Ignacio I.. (2014) The ubiquilin gene family: evolutionary patterns and functional insights.. BMC evolutionary biology, (28): [PMID:24674348] |
| 24. Gilpin, Kathleen M KM, Chang, Lydia L and Monteiro, Mervyn J MJ.. (2015) ALS-linked mutations in ubiquilin-2 or hnRNPA1 reduce interaction between ubiquilin-2 and hnRNPA1.. Human molecular genetics, (1): [PMID:25616961] |
