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UCB35625 , CAS No.U614613, Antagonist of CCR1;Antagonist of CCR3

  • Moligand™
Item Number
U614613
Grouped product items
SKUSizeAvailabilityPrice Qty
U614613-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$560.90
U614613-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,500.90
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CCR1 Antagonist CCR3 Antagonist

Basic Description

SynonymsUCB 35625;UCB-35625
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionAntagonist of CCR1;Antagonist of CCR3

Associated Targets

CCR3 Tchem C-C chemokine receptor type 3 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CCR1 Tchem C-C chemokine receptor type 1 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 1-(cycloheptylmethyl)-4-(2,7-dichloro-9H-xanthene-9-amido)-1-ethylpiperidin-1-ium
INCHI InChI=1S/C29H36Cl2N2O2/c1-2-33(19-20-7-5-3-4-6-8-20)15-13-23(14-16-33)32-29(34)28-24-17-21(30)9-11-26(24)35-27-12-10-22(31)18-25(27)28/h9-12,17-18,20,23,28H,2-8,13-16,19H2,1H3/p+1
InChi Key ZTXGBIXSMSZDOC-UHFFFAOYSA-O
Canonical SMILES CC[N+]1(CCC(CC1)NC(=O)C1c2cc(Cl)ccc2Oc2c1cc(Cl)cc2)CC1CCCCCC1
Isomeric SMILES CC[N+]1(CCC(CC1)NC(=O)C2C3=C(C=CC(=C3)Cl)OC4=C2C=C(C=C4)Cl)CC5CCCCCC5
PubChem CID 44560289

Certificates

Certificate of Analysis(COA)

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Related Documents

 SDS

 Specification Sheet

References

1. Sabroe I, Peck MJ, Van Keulen BJ, Jorritsma A, Simmons G, Clapham PR, Williams TJ, Pease JE.  (2000)  A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry..  J Biol Chem,  275  (34): (25985-92).  [PMID:10854442]
2. Laurent V, Guérard A, Mazerolles C, Le Gonidec S, Toulet A, Nieto L, Zaidi F, Majed B, Garandeau D, Socrier Y et al..  (2016)  Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity..  Nat Commun,  7  (3): (10230).  [PMID:26756352]

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