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UE2343 , CAS No.1346013-80-6, Inhibitor of CYP2C19;Inhibitor of hydroxysteroid 11-beta dehydrogenase 1

  • Moligand™
Item Number
U614639
Grouped product items
SKUSizeAvailabilityPrice Qty
U614639-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$560.90
U614639-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,500.90
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CYP2C19 Inhibitor hydroxysteroid 11-beta dehydrogenase 1 Inhibitor

Basic Description

Synonymscompound 4;UE-2343;Xanamem
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of CYP2C19;Inhibitor of hydroxysteroid 11-beta dehydrogenase 1

Associated Targets

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HSD11B1 Tclin Corticosteroid 11-beta-dehydrogenase isozyme 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name [(1S,5R)-3-hydroxy-3-pyrimidin-2-yl-8-azabicyclo[3.2.1]octan-8-yl]-[5-(1H-pyrazol-4-yl)thiophen-3-yl]methanone
INCHI InChI=1S/C19H19N5O2S/c25-17(12-6-16(27-11-12)13-9-22-23-10-13)24-14-2-3-15(24)8-19(26,7-14)18-20-4-1-5-21-18/h1,4-6,9-11,14-15,26H,2-3,7-8H2,(H,22,23)/t14-,15+,19?
InChi Key MMZFGTAMARVHAF-RTHVDDQRSA-N
Canonical SMILES C1C[C@H]2CC(C[C@@H]1N2C(=O)c1csc(c1)c1c[nH]nc1)(c1ncccn1)O
PubChem CID 137530063

Certificates

Certificate of Analysis(COA)

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Related Documents

 SDS

 Specification Sheet

References

1. Webster SP, McBride A, Binnie M, Sooy K, Seckl JR, Andrew R, Pallin TD, Hunt HJ, Perrior TR, Ruffles VS et al..  (2017)  Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™)..  Br J Pharmacol,  174  (5): (396-408).  [PMID:28012176]

Solution Calculators

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