Grouped product items

SKU

Size

Availability

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Qty

U287064-1mg

1mg

In stock

$23.90

U287064-5mg

5mg

In stock

$97.90

U287064-10mg

10mg

In stock

$162.90

U287064-50mg

50mg

In stock

$489.90

Basic Description

Synonyms	UNC0642\|1481677-78-4\|UNC 0642\|UNC-0642\|2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine\|2-(4,4-difluoropiperidin-1-yl)-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-
Specifications & Purity	Moligand™, ≥99%(HPLC)
Biochemical and Physiological Mechanisms	Potent and selective G9a and GLP histone lysine methyltransferase inhibitor (IC50< 2.5 nM). Exhibits >2,000-fold selectivity for G9a and GLP over PRC2-EZH2 and >20,000-fold selectivity over other methyltransferases. Reduces H3K9 dimethylation levels in MD
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of euchromatic histone lysine methyltransferase 1;Inhibitor of euchromatic histone lysine methyltransferase 2

Associated Targets

DNMT1 Tclin DNA (cytosine-5)-methyltransferase 1 0 Activities

Discover Target: DNMT1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 6 Activities

Discover Target: EHMT2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EZH2 Tclin Histone-lysine N-methyltransferase EZH2 0 Activities

Discover Target: EZH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EHMT1 Tchem Histone-lysine N-methyltransferase EHMT1 1 Activities

Discover Target: EHMT1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRD4 Tchem Bromodomain-containing protein 4 0 Activities

Discover Target: BRD4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

Discover Target: CDK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SUV39H2 Tchem Histone-lysine N-methyltransferase SUV39H2 0 Activities

Discover Target: SUV39H2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HRH3 Tclin Histamine H3 receptor 1 Activities

Discover Target: HRH3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities

Discover Target: KMT2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KMT5A Tchem N-lysine methyltransferase KMT5A 0 Activities

Discover Target: KMT5A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KMT5B Tchem Histone-lysine N-methyltransferase KMT5B 0 Activities

Discover Target: KMT5B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KMT5C Tchem Histone-lysine N-methyltransferase KMT5C 0 Activities

Discover Target: KMT5C

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

Discover Target: FGFR3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CSNK1D Tchem Casein kinase I isoform delta 0 Activities

Discover Target: CSNK1D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SETDB1 Tbio Histone-lysine N-methyltransferase SETDB1 0 Activities

Discover Target: SETDB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRIM24 Tchem Transcription intermediary factor 1-alpha 0 Activities

Discover Target: TRIM24

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SETD7 Tchem Histone-lysine N-methyltransferase SETD7 0 Activities

Discover Target: SETD7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CARM1 Tchem Histone-arginine methyltransferase CARM1 0 Activities

Discover Target: CARM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRMT5 Tchem Protein arginine N-methyltransferase 5 0 Activities

Discover Target: PRMT5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRPF1 Tchem Peregrin 0 Activities

Discover Target: BRPF1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRMT1 Tchem Protein arginine N-methyltransferase 1 0 Activities

Discover Target: PRMT1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AURKA Tchem Aurora kinase A 0 Activities

Discover Target: AURKA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA2C Tclin Alpha-2C adrenergic receptor 0 Activities

Discover Target: ADRA2C

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRMT8 Tchem Protein arginine N-methyltransferase 8 0 Activities

Discover Target: PRMT8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

Discover Target: ABL1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA1D Tclin Alpha-1D adrenergic receptor 0 Activities

Discover Target: ADRA1D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKAA1 Tclin 5'-AMP-activated protein kinase catalytic subunit alpha-1 0 Activities

Discover Target: PRKAA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRMT3 Tchem Protein arginine N-methyltransferase 3 0 Activities

Discover Target: PRMT3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

Discover Target: GSK3B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OPRM1 Tclin Mu-type opioid receptor 0 Activities

Discover Target: OPRM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Discover Target: MAPK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-(4,4-difluoropiperidin-1-yl)-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine
INCHI	InChI=1S/C29H44F2N6O2/c1-21(2)36-14-7-22(8-15-36)32-27-23-19-25(38-3)26(39-18-6-13-35-11-4-5-12-35)20-24(23)33-28(34-27)37-16-9-29(30,31)10-17-37/h19-22H,4-18H2,1-3H3,(H,32,33,34)
InChi Key	RNAMYOYQYRYFQY-UHFFFAOYSA-N
Canonical SMILES	CC(C)N1CCC(CC1)NC2=NC(=NC3=CC(=C(C=C32)OC)OCCCN4CCCC4)N5CCC(CC5)(F)F
Isomeric SMILES	CC(C)N1CCC(CC1)NC2=NC(=NC3=CC(=C(C=C32)OC)OCCCN4CCCC4)N5CCC(CC5)(F)F
Alternate CAS	1481677-78-4
PubChem CID	53315878
MeSH Entry Terms	2-(4,4-difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine;UNC0642
Molecular Weight	546.7

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

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4 results found

Lot Number	Certificate Type	Date	Item
E2216051	Certificate of Analysis	Feb 22, 2022	U287064
E2216055	Certificate of Analysis	Feb 22, 2022	U287064
E2216060	Certificate of Analysis	Feb 22, 2022	U287064
E2216066	Certificate of Analysis	Feb 22, 2022	U287064

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 54.67, Max Conc. mM: 100; Solvent:1eq. HCl, Max Conc. mg/mL: 27.34, Max Conc. mM: 50

References

1. Liu F, Barsyte-Lovejoy D, Li F, Xiong Y, Korboukh V, Huang XP, Allali-Hassani A, Janzen WP, Roth BL, Frye SV et al.. (2013) Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.. J Med Chem, 56 (21): (8931-42). [PMID:24102134]

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UNC 0642 - ≥99%(HPLC), high purity , CAS No.1481677-78-4, Inhibitor of euchromatic histone lysine methyltransferase 1;Inhibitor of euchromatic histone lysine methyltransferase 2

Basic Description

Associated Targets

DNMT1 Tclin DNA (cytosine-5)-methyltransferase 1 0 Activities

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 6 Activities

EZH2 Tclin Histone-lysine N-methyltransferase EZH2 0 Activities

EHMT1 Tchem Histone-lysine N-methyltransferase EHMT1 1 Activities

BRD4 Tchem Bromodomain-containing protein 4 0 Activities

CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

SUV39H2 Tchem Histone-lysine N-methyltransferase SUV39H2 0 Activities

HRH3 Tclin Histamine H3 receptor 1 Activities

KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities

KMT5A Tchem N-lysine methyltransferase KMT5A 0 Activities

KMT5B Tchem Histone-lysine N-methyltransferase KMT5B 0 Activities

HDAC6 Tclin Histone deacetylase 6 0 Activities

KMT5C Tchem Histone-lysine N-methyltransferase KMT5C 0 Activities

FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

CSNK1D Tchem Casein kinase I isoform delta 0 Activities

SETDB1 Tbio Histone-lysine N-methyltransferase SETDB1 0 Activities

TRIM24 Tchem Transcription intermediary factor 1-alpha 0 Activities

SETD7 Tchem Histone-lysine N-methyltransferase SETD7 0 Activities

CARM1 Tchem Histone-arginine methyltransferase CARM1 0 Activities

PRMT5 Tchem Protein arginine N-methyltransferase 5 0 Activities

BRPF1 Tchem Peregrin 0 Activities

PRMT1 Tchem Protein arginine N-methyltransferase 1 0 Activities

AURKA Tchem Aurora kinase A 0 Activities

ADRA2C Tclin Alpha-2C adrenergic receptor 0 Activities

PRMT8 Tchem Protein arginine N-methyltransferase 8 0 Activities

ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

ADRA1D Tclin Alpha-1D adrenergic receptor 0 Activities

PRKAA1 Tclin 5'-AMP-activated protein kinase catalytic subunit alpha-1 0 Activities

PRMT3 Tchem Protein arginine N-methyltransferase 3 0 Activities

GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

OPRM1 Tclin Mu-type opioid receptor 0 Activities

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

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References

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