UNC1062 is a MERTK -selective tyrosine kinase inhibitor, reduces activation of MERTK-mediated downstream signaling, induces apoptosis in culture, reduces colony formation in soft agar, and inhibits invasion of melanoma cells. UNC1062 potently inhibits MER
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Store at -20°C
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Product Description
UNC1062 is a MERTK -selective tyrosine kinase inhibitor, reduces activation of MERTK-mediated downstream signaling, induces apoptosis in culture, reduces colony formation in soft agar, and inhibits invasion of melanoma cells. UNC1062 potently inhibits MERTK kinase activity (MERTK IC 50 =1.1 nM, Morrison K i =0.33 nM) and exhibits specificity within the TAM family (TYRO3 IC 50 =60 nM, AXL IC 50 =85 nM).
