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URB 937 - 98%, high purity , CAS No.1357160-72-5, Inhibitor of Fatty acid amide hydrolase

  • Moligand™
  • ≥98%
Item Number
U351248
Grouped product items
SKUSizeAvailabilityPrice Qty
U351248-5mg
5mg
In stock
$98.90
U351248-10mg
10mg
In stock
$167.90
U351248-25mg
25mg
In stock
$378.90
U351248-50mg
50mg
In stock
$503.90
U351248-100mg
100mg
In stock
$907.90
U351248-200mg
200mg
In stock
$1,632.90
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Fatty acid amide hydrolase Inhibitor

Basic Description

SynonymsURB937|1357160-72-5|3'-carbamoyl-6-hydroxybiphenyl-3-yl cyclohexylcarbamate|URB 937|URB-937|CHEMBL2402927|[3-(3-carbamoylphenyl)-4-hydroxyphenyl] N-cyclohexylcarbamate|3'-Carbamoyl-6-hydroxy-[1,1'-biphenyl]-3-yl cyclohexylcarbamate|SCHEMBL528582|GTPL11817
Specifications & Purity98%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of Fatty acid amide hydrolase
Product Description

Product description

URB937 is an orally active and peripherally restricted FAAH inhibitor (IC50=26.8 nM) and increases anandamide levels. URB937 fails to affect FAAH activity in the brain (not penetrate the blood-brain barrier).

Associated Targets

FAAH Tchem Fatty-acid amide hydrolase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name [3-(3-carbamoylphenyl)-4-hydroxyphenyl] N-cyclohexylcarbamate
INCHI InChI=1S/C20H22N2O4/c21-19(24)14-6-4-5-13(11-14)17-12-16(9-10-18(17)23)26-20(25)22-15-7-2-1-3-8-15/h4-6,9-12,15,23H,1-3,7-8H2,(H2,21,24)(H,22,25)
InChi Key CMEQHOXCIGFZNJ-UHFFFAOYSA-N
Canonical SMILES C1CCC(CC1)NC(=O)OC2=CC(=C(C=C2)O)C3=CC(=CC=C3)C(=O)N
Isomeric SMILES C1CCC(CC1)NC(=O)OC2=CC(=C(C=C2)O)C3=CC(=CC=C3)C(=O)N
WGK Germany 3
PubChem CID 53394762
Molecular Weight 354.4

Certificates

Certificate of Analysis(COA)

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6 results found

Lot NumberCertificate TypeDateItem
C23081457Certificate of AnalysisDec 01, 2022 U351248
C23081470Certificate of AnalysisDec 01, 2022 U351248
C23081471Certificate of AnalysisDec 01, 2022 U351248
C23081472Certificate of AnalysisDec 01, 2022 U351248
C23081477Certificate of AnalysisDec 01, 2022 U351248
C23081480Certificate of AnalysisDec 01, 2022 U351248

Safety and Hazards(GHS)

WGK Germany 3
RIDADR NONHforallmodesoftransport

Related Documents

 SDS

 Specification Sheet

References

1. Slivicki RA, Xu Z, Mali SS, Hohmann AG.  (2019)  Brain permeant and impermeant inhibitors of fatty-acid amide hydrolase suppress the development and maintenance of paclitaxel-induced neuropathic pain without producing tolerance or physical dependence in vivo and synergize with paclitaxel to reduce tumor cell line viability in vitro..  Pharmacol Res,  142  (3): (267-282).  [PMID:30739035]

Solution Calculators

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