Oxidase, urate|9002-12-4|azane;[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl [5-(2,4-dioxopyrimidin-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate|Uricase from Bacillus fastidiosus|VPXDHZMLJOJKOX-UHFFFAOYSA-N|FT-0686693|FT
Specifications & Purity
≥2 units/mg dry weight
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
EnzymoPure™
Product Description
Uricase from Candida yeast has a molecular weight of ~120,000 daltons and an optimum pH of 8.5. The enzyme is stable at pH 8.5-9.5 and at temperatures below 35°C. The pI is 5.6. It is inhibited by various purine analogs of urate, and by copper chelating agents. The enzyme is highly specific for uric acid. Mice deficient in uricase develop uric acid nephropathy and diabetes insipidus which can be mitigated with recombinant uricase treatment. Oxidizes uric acid
D2429469