| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| V655112-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $431.90 |
| Specifications & Purity | 10mM in Water |
|---|---|
| Biochemical and Physiological Mechanisms | Vaborbactam (RPX7009) is a cyclic boronic acid pharmacophore β-lactamase inhibitor. |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Vaborbactam (RPX7009) is a cyclic boronic acid pharmacophore β-lactamase inhibitor. In Vitro Vaborbactam is a broad spectrum of inhibition of β-lactamases, with particularly potent activity against KPC, CTX-M, SHV, and CMY enzymes. Vaborbactam restores SM 7338 activity for 72.7 to 98.1% of CPE isolates at ≤2 μg/mL, and maximum potentiation is achieved with fixed concentrations of ≥8 μg/mL of the inhibitor (≥96.5% of isolates are inhibited at ≤2 μg/mL of SM 7338-vaborbactam). SM 7338-vaborbactam with a fixed concentration of 8 μg/mL of the inhibitor (MIC50, ≤0.06 μg/mL for all organisms) inhibits 93.7% of the CPE isolates displaying elevated SM 7338 MICs at ≤1 μg/mL. By forming a reversible dative bond with the blactamase, vaborbactam acts as a competitive inhibitor and is not hydrolyzed by the b-lactamase. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Vaborbactam is well tolerated and has a half-life of 1.23 h, and steadystate volume of distribution of 21.0 L in subjects. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Canonical SMILES | B1(C(CCC(O1)CC(=O)O)NC(=O)CC2=CC=CS2)O |
|---|---|
| Molecular Weight | 297.14 |
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