Grouped product items

SKU

Size

Availability

Price

Qty

V302465-1mg

1mg

In stock

$18.90

V302465-5mg

5mg

In stock

$78.90

V302465-10mg

10mg

In stock

$117.90

V302465-25mg

25mg

In stock

$197.90

V302465-50mg

50mg

Available within 4-8 weeks(?)

$305.90

V302465-100mg

100mg

Available within 4-8 weeks(?)

$474.90

V302465-250mg

250mg

Available within 4-8 weeks(?)

$1,068.90

Basic Description

Synonyms	vactosertib\|1352608-82-2\|EW-7197\|EW 7197\|TEW-7197\|TEW 7197\|EW7197\|N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline\|CHEMBL3260567\|6T4O391P5Y\|2-fluoro-N-[[5-(6-methylpyridin-2-yl)-4-([1,2,4]triazol
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	TGF-beta receptor type I inhibitor

Product Properties

ALogP	3.2

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Discover Target: CYP1A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

Discover Target: CYP2D6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRD4 Tchem Bromodomain-containing protein 4 0 Activities

Discover Target: BRD4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Discover Target: CYP2C9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

Discover Target: CDK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FLT4 Tclin Vascular endothelial growth factor receptor 3 0 Activities

Discover Target: FLT4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

Discover Target: FGFR3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CSNK1D Tchem Casein kinase I isoform delta 0 Activities

Discover Target: CSNK1D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TGFBR1 Tchem TGF-beta receptor type-1 10 Activities

Discover Target: TGFBR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TGFBR2 Tchem TGF-beta receptor type-2 0 Activities

Discover Target: TGFBR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRIM24 Tchem Transcription intermediary factor 1-alpha 0 Activities

Discover Target: TRIM24

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDGFRA Tclin Platelet-derived growth factor receptor alpha 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RIPK2 Tchem Receptor-interacting serine/threonine-protein kinase 2 0 Activities

Discover Target: RIPK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MINK1 Tchem Misshapen-like kinase 1 0 Activities

Discover Target: MINK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAP4K4 Tchem Mitogen-activated protein kinase kinase kinase kinase 4 0 Activities

Discover Target: MAP4K4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BMPR1B Tchem Bone morphogenetic protein receptor type-1B 0 Activities

Discover Target: BMPR1B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRPF1 Tchem Peregrin 0 Activities

Discover Target: BRPF1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BMPR1A Tchem Bone morphogenetic protein receptor type-1A 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AURKA Tchem Aurora kinase A 0 Activities

Discover Target: AURKA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FLT1 Tclin Vascular endothelial growth factor receptor 1 0 Activities

Discover Target: FLT1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDR Tclin Vascular endothelial growth factor receptor 2 0 Activities

Discover Target: KDR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACVR1 Tchem Activin receptor type-1 0 Activities

Discover Target: ACVR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

Discover Target: ABL1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACVRL1 Tchem Serine/threonine-protein kinase receptor R3 0 Activities

Discover Target: ACVRL1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACVR1B Tchem Activin receptor type-1B 2 Activities

Discover Target: ACVR1B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TGFB1 Tbio Transforming growth factor beta-1 proprotein 0 Activities

Discover Target: TGFB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

Discover Target: GSK3B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Discover Target: MAPK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK14 Tchem Mitogen-activated protein kinase 14 0 Activities

Discover Target: MAPK14

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-fluoro-N-[[5-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-imidazol-2-yl]methyl]aniline
INCHI	InChI=1S/C22H18FN7/c1-14-5-4-8-18(27-14)22-21(15-9-10-20-25-13-26-30(20)12-15)28-19(29-22)11-24-17-7-3-2-6-16(17)23/h2-10,12-13,24H,11H2,1H3,(H,28,29)
InChi Key	FJCDSQATIJKQKA-UHFFFAOYSA-N
Canonical SMILES	CC1=NC(=CC=C1)C2=C(N=C(N2)CNC3=CC=CC=C3F)C4=CN5C(=NC=N5)C=C4
Isomeric SMILES	CC1=NC(=CC=C1)C2=C(N=C(N2)CNC3=CC=CC=C3F)C4=CN5C(=NC=N5)C=C4
PubChem CID	54766013
Molecular Weight	399.43

Database links

PubChem CID	54766013
CAS Registry No.	1352608-82-2
ChEMBL Ligand	CHEMBL3260567

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

7 results found

Lot Number	Certificate Type	Date	Item
A2215466	Certificate of Analysis	Dec 29, 2021	V302465
A2217003	Certificate of Analysis	Dec 29, 2021	V302465
A2217004	Certificate of Analysis	Dec 29, 2021	V302465
A2217005	Certificate of Analysis	Dec 29, 2021	V302465
A2217009	Certificate of Analysis	Dec 29, 2021	V302465
A2217012	Certificate of Analysis	Dec 29, 2021	V302465
A2217031	Certificate of Analysis	Dec 29, 2021	V302465

Chemical and Physical Properties

Solubility	≥39.9 mg/mL in DMSO; insoluble in H2O; ≥4.55 mg/mL in EtOH with ultrasonic
Melt Point(°C)	>85ºC (dec.)

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

References

1. Jin CH, Krishnaiah M, Sreenu D, Subrahmanyam VB, Rao KS, Lee HJ, Park SJ, Park HJ, Lee K, Sheen YY et al.. (2014) Discovery of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline (EW-7197): a highly potent, selective, and orally bioavailable inhibitor of TGF-β type I receptor kinase as cancer immunotherapeutic/antifibrotic agent.. J Med Chem, 57 (10): (4213-38). [PMID:24786585]

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Vactosertib (TEW-7197) - 98%, high purity , TGF-beta receptor type I inhibitor, CAS No.1352608-82-2, TGF-beta receptor type I inhibitor

Basic Description

Product Properties

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

BRD4 Tchem Bromodomain-containing protein 4 0 Activities

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

FLT4 Tclin Vascular endothelial growth factor receptor 3 0 Activities

HDAC6 Tclin Histone deacetylase 6 0 Activities

FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

CSNK1D Tchem Casein kinase I isoform delta 0 Activities

TGFBR1 Tchem TGF-beta receptor type-1 10 Activities

TGFBR2 Tchem TGF-beta receptor type-2 0 Activities

TRIM24 Tchem Transcription intermediary factor 1-alpha 0 Activities

PDGFRA Tclin Platelet-derived growth factor receptor alpha 0 Activities

RIPK2 Tchem Receptor-interacting serine/threonine-protein kinase 2 0 Activities

MINK1 Tchem Misshapen-like kinase 1 0 Activities

MAP4K4 Tchem Mitogen-activated protein kinase kinase kinase kinase 4 0 Activities

BMPR1B Tchem Bone morphogenetic protein receptor type-1B 0 Activities

BRPF1 Tchem Peregrin 0 Activities

BMPR1A Tchem Bone morphogenetic protein receptor type-1A 0 Activities

AURKA Tchem Aurora kinase A 0 Activities

FLT1 Tclin Vascular endothelial growth factor receptor 1 0 Activities

KDR Tclin Vascular endothelial growth factor receptor 2 0 Activities

ACVR1 Tchem Activin receptor type-1 0 Activities

ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

ACVRL1 Tchem Serine/threonine-protein kinase receptor R3 0 Activities

ACVR1B Tchem Activin receptor type-1B 2 Activities

TGFB1 Tbio Transforming growth factor beta-1 proprotein 0 Activities

GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

MAPK14 Tchem Mitogen-activated protein kinase 14 0 Activities

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

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