The store will not work correctly when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
Valrubicin , DNA inhibitor, CAS No.56124-62-0, DNA inhibitor
a chemotherapy drug used to treat cancer
Basic Description Synonyms Valrubicin|56124-62-0|Valstar|AD-32|Antibiotic AD 32|Valstar Preservative Free|AD 32|NSC-246131|UNII-2C6NUM6878|N-Trifluoroacetyldoxorubicin 14-valerate|DTXSID9046497|HSDB 7288|2C6NUM6878|Valrubicin (AD-32)|N-Trifluoroacetyladriamycin-14-valerate|NSC 2461 Biochemical and Physiological Mechanisms Valrubicin is a semisynthetic derivative of the antineoplastic anthracycline antibiotic doxorubicin. Valrubicin is converted intracytoplasmically into N-trifluoroacetyladriamycin, which interacts with topoisomerase II, stabilizing the complex between the Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Action Type INHIBITOR Mechanism of action DNA inhibitor Product Description Valrubicin is a chemotherapy drug used to treat cancer of the bladder.
Names and Identifiers IUPAC Name [2-oxo-2-[(2S,4S)-2,5,12-trihydroxy-4-[(2R,4S,5S,6S)-5-hydroxy-6-methyl-4-[(2,2,2-trifluoroacetyl)amino]oxan-2-yl]oxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]ethyl] pentanoate INCHI InChI=1S/C34H36F3NO13/c1-4-5-9-21(40)49-13-20(39)33(47)11-16-24(19(12-33)51-22-10-17(27(41)14(2)50-22)38-32(46)34(35,36)37)31(45)26-25(29(16)43)28(42)15-7-6-8-18(48-3)23(15)30(26)44/h6-8,14,17,19,22,27,41,43,45,47H,4-5,9-13H2,1-3H3,(H,38,46)/t14-,17-,19-,22-,27+,33-/m0/s1 InChi Key ZOCKGBMQLCSHFP-KQRAQHLDSA-N Canonical SMILES CCCCC(=O)OCC(=O)C1(CC(C2=C(C1)C(=C3C(=C2O)C(=O)C4=C(C3=O)C=CC=C4OC)O)OC5CC(C(C(O5)C)O)NC(=O)C(F)(F)F)O Isomeric SMILES CCCCC(=O)OCC(=O)[C@]1(C[C@@H](C2=C(C1)C(=C3C(=C2O)C(=O)C4=C(C3=O)C=CC=C4OC)O)O[C@H]5C[C@@H]([C@@H]([C@@H](O5)C)O)NC(=O)C(F)(F)F)O PubChem CID 454216 Molecular Weight 723.64
Chemical and Physical Properties Solubility Soluble in DMSO, and methanol. Melt Point(°C) 202-205° C
Safety and Hazards(GHS) Pictogram(s) GHS06 , GHS08 , GHS07 Signal Danger Hazard Statements H301: Toxic if swallowed
H351: Suspected of causing cancer
H312: Harmful in contact with skin
H332: Harmful if inhaled
H360: May damage fertility or the unborn child
H340: May cause genetic defects
H350: May cause cancer
H361: Suspected of damaging fertility or the unborn child
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P281: Use personal protective equipment as required.
P271: Use only outdoors or in a well-ventilated area.
P270: Do not eat, drink or smoke when using this product.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P362+P364: Take off contaminated clothing and wash it before reuse.
P330: Rinse mouth.
P203: Obtain, read and follow all safety instructions before use.
P301+P316: IF SWALLOWED: Get emergency medical help immediately.
P318: if exposed or concerned, get medical advice.
P317: Get emergency medical help.
Solution Calculators Molarity Calculator Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator
D2419171