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Vancomycin HCL - USP grade,potency: ≥900 ug per mg, high purity , CAS No.1404-93-9

43 Citations
Item Number
V105495
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SKUSizeAvailabilityPrice Qty
V105495-250mg
250mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$19.90
V105495-1g
1g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$49.90
V105495-5g
5g
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Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$139.90
V105495-25g
25g
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Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$399.90
V105495-100g
100g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,119.90
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Tricyclic glycopeptide antibiotic

Basic Description

SynonymsVANCOMYCIN HYDROCHLORIDE (EP MONOGRAPH) | EN300-26256009 | Vancocin hydrochloride in plastic container | CCG-222571 | VANCOMYCIN MONOHYDROCHLORIDE [MI] | VANCOMYCINHYDROCHLORIDE | VANCOMYCIN HYDROCHLORIDE [ORANGE BOOK] | UNII-71WO621TJD | DTXSID90891868 |
Specifications & PurityPharmPure™, USP, potency: ≥900 ug per mg
Biochemical and Physiological MechanismsVancomycin is a glycopeptide antibiotic that blocks bacterial cell wall biosynthesis at the level of peptidoglycan biosynthesis. It inhibits incorporation of terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides. It is effective against Gram-positi
Storage TempStore at 2-8°C,Argon charged
Shipped InWet ice
GradePharmPure™, USP
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Vancomycin, from Streptomyces orientalis, is used for the treatment of serious or severe infections caused by susceptible strains of methicillin-resistant (β-lactam-resistant) staphylococci. It is used to block bacterial cell wall biosynthesis at the level of peptidoglycan biosynthesis. It is widely studied in cancer patients.Vancomycin′s overuse has been studied, which has resulted in recommended guidelines.

Names and Identifiers

IUPAC Name (1S,2R,18R,19R,22S,25R,28R,40S)-48-[(2S,3R,4S,5S,6R)-3-[(2S,4S,5S,6S)-4-amino-5-hydroxy-4,6-dimethyloxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-22-(2-amino-2-oxoethyl)-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[[(2R)-4-methyl-2-(methylamino)pentanoyl]amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentazaoctacyclo[26.14.2.23,6.214,17.18,12.129,33.010,25.034,39]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34(39),35,37,46,49-pentadecaene-40-carboxylic acid;hydrochloride
INCHI InChI=1S/C66H75Cl2N9O24.ClH/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92;/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95);1H/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-;/m0./s1
InChi Key LCTORFDMHNKUSG-XTTLPDOESA-N
Canonical SMILES CC1C(C(CC(O1)OC2C(C(C(OC2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)C(C(C(=O)NC(C(=O)NC5C(=O)NC7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9O)O)C(NC(=O)C(C(C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O)CC(=O)N)NC(=O)C(CC(C)C)NC)O)Cl)CO)O)O)(C)N)O.Cl
Isomeric SMILES C[C@H]1[C@H]([C@@](C[C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)[C@H]([C@H](C(=O)N[C@H](C(=O)N[C@H]5C(=O)N[C@@H]7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9O)O)[C@H](NC(=O)[C@H]([C@@H](C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O)CC(=O)N)NC(=O)[C@@H](CC(C)C)NC)O)Cl)CO)O)O)(C)N)O.Cl
WGK Germany 2
RTECS YW4380000
PubChem CID 6420023
Molecular Weight 1485.71
Beilstein 3704657

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

13 results found

Lot NumberCertificate TypeDateItem
J2327209Certificate of AnalysisOct 30, 2023 V105495
G2304033Certificate of AnalysisJul 07, 2023 V105495
L2319118Certificate of AnalysisJul 07, 2023 V105495
C2303160Certificate of AnalysisMar 07, 2023 V105495
A2309488Certificate of AnalysisJan 16, 2023 V105495
A2309413Certificate of AnalysisJan 13, 2023 V105495
F2417064Certificate of AnalysisAug 05, 2022 V105495
G2225068Certificate of AnalysisAug 05, 2022 V105495
G2306129Certificate of AnalysisAug 05, 2022 V105495
K2408074Certificate of AnalysisAug 05, 2022 V105495
F2417045Certificate of AnalysisAug 27, 2021 V105495
H2416056Certificate of AnalysisAug 27, 2021 V105495
K2306166Certificate of AnalysisAug 27, 2021 V105495

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Chemical and Physical Properties

SolubilitySoluble in water. Slightly soluble in methanol, ethanol and dimethylsulfoxide.
SensitivityHygroscopic

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H317:May cause an allergic skin reaction

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 2
RTECS YW4380000

Related Documents

 SDS

 Specification Sheet

FAQs and Articles

FAQ
Antimicrobial Peptides: A Promising Field in Antibiotic Research
Categories: Technical articles
Tags:
Antibiotics Natural products Immunology Antimicrobial ligands Peptides WHO Essential Medicine ligands Human endogenous peptides Antimicrobial peptides RAMPs Biology of Cells

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Xiang Jin, Dongxu Xie, Zhenbao Zhang, Aobo Liu, Menglin Wang, Jiabao Dai, Xuan Wang, Huanze Deng, Yijie Liang, Yantao Zhao, Peng Wen, Yanfeng Li.  (2024)  In vitro and in vivo studies on biodegradable Zn porous scaffolds with a drug-loaded coating for the treatment of infected bone defect.  Materials Today Bio,  24  (1): (100885).  [PMID:38169782]
2. Xinyi Zhong, Kai Deng, Xiuhan Yang, Xu Song, Yuanfeng Zou, Xun Zhou, Huaqiao Tang, Lixia Li, Yuping Fu, Zhongqiong Yin, Hongping Wan, Xinghong Zhao.  (2023)  Brevicidine acts as an effective sensitizer of outer membrane-impermeable conventional antibiotics for Acinetobacter baumannii treatment.  Frontiers in Microbiology,  14  (1304198).  [PMID:38173680]
3. Yechang Guo, Shaofeng Wang, Peiyue Li, Pan Zhang, Wei Wang.  (2023)  Rapid Colloidal Gold Immunoassay for Pharmacokinetic Evaluation of Vancomycin in the Cerebrospinal Fluid and Plasma of Beagle Dogs.  SENSORS,  23  (21): (8978).  [PMID:37960677]
4. Xiao-Ling Lei, Kai Cheng, Yong-Guo Hu, Yong Li, Xiao-Lin Hou, Fang Zhang, Lin-Fang Tan, Zi-Tao Zhong, Jian-Hao Wang, Jin-Xuan Fan, Yuan-Di Zhao.  (2023)  Gelatinase-responsive biodegradable targeted microneedle patch for abscess wound treatment of S. aureus infection.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  253  (127548).  [PMID:37865374]
5. Yufei Liu, Yao Qi, Chen Chen, Yincheng Jin, Shi Du, Jianan Qiao, Jing Yao.  (2023)  Platelet-mimetic nano-sensor for combating postoperative recurrence and wound infection of triple-negative breast cancer.  JOURNAL OF CONTROLLED RELEASE,  362  (16): (396).  [PMID:37657692]
6. Qiao Chen-Meng, Zhou Yu, Quan Wei, Ma Xiao-Yu, Zhao Li-Ping, Shi Yun, Hong Hui, Wu Jian, Niu Gu-Yu, Chen Yu-Nuo, Zhu Shan, Cui Chun, Zhao Wei-Jiang, Shen Yan-Qin.  (2023)  Fecal Microbiota Transplantation from Aged Mice Render Recipient Mice Resistant to MPTP-Induced Nigrostriatal Degeneration Via a Neurogenesis-Dependent but Inflammation-Independent Manner.  Neurotherapeutics,    (1-22).  [PMID:37596429]
7. Han Zhao, Kai Liu, Lijie Zhou, Tingting Zhang, Zengsheng Han, Longgang Wang, Xianbing Ji, Yanshuai Cui, Jie Hu, Guanglong Ma.  (2023)  Platinum Palladium Bimetallic Nanozymes Stabilized with Vancomycin for the Sensitive Colorimetric Determination of L-cysteine.  Biomolecules,  13  (8): (1254).  [PMID:37627319]
8. Xinshu Zou, Shuang Cai, Tingting Wang, Sidi Zheng, Xilong Cui, Jingyou Hao, Xueying Chen, Yanyan Liu, Zhiyun Zhang, Yanhua Li.  (2023)  Natural Antibacterial Agent-based Nanoparticles for Effective Treatment of Intracellular MRSA Infection.  Acta Biomaterialia,      [PMID:37557944]
9. Shoubei Gao, Kai Liu, Xianbing Ji, Yanshuai Cui, Ruyu Li, Guanglong Ma, Yongqiang Zhang, Longgang Wang.  (2023)  Biocompatible Palladium Nanoparticles Prepared Using Vancomycin for Colorimetric Detection of Hydroquinone.  Polymers,  15  (14): (3148).  [PMID:37514537]
10. Jiao Wei, Zongmei Zheng, Xinxin Hou, Fengjing Jia, Yuan Yuan, Fuwen Yuan, Feng He, Liang Hu, Ling Zhao.  (2024)  Echinacoside inhibits colorectal cancer metastasis via modulating the gut microbiota and suppressing the PI3K/AKT signaling pathway.  JOURNAL OF ETHNOPHARMACOLOGY,  318  (116866).  [PMID:37429503]
11. Wenbo He, Zhaoyang Yao, Youlu Diao, Miao Wang, Guoqing Pan.  (2023)  Dynamic display of cell targeting motifs via natural glycopeptide recognition for cancer cell isolation.  Materials Chemistry Frontiers,      [PMID:]
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13. Leilei Sun, Yao Huang, Chenhui Ji, Craig A. Grimes, Qingyun Cai.  (2023)  NIR-II multiplexed fluorescence imaging of bacteria based on excitation-selective lanthanide-doped core-shell nanoparticles.  SENSORS AND ACTUATORS B-CHEMICAL,  384  (133669).  [PMID:]
14. Yajie Cai, Xiaojiaoyang Li, Qi Han, Jinzhao Bai, Qi Zheng, Rong Sun, Runping Liu.  (2023)  Si–Ni-San improves experimental colitis by favoring Akkermensia colonization.  JOURNAL OF ETHNOPHARMACOLOGY,  305  (116067).  [PMID:36586523]
15. Xingyue Wang, Xu Fang, Xin Gao, Hao Wang, Shihuai Li, Chen Li, Yunan Qing, Yanguo Qin.  (2022)  Strong adhesive and drug-loaded hydrogels for enhancing bone–implant interface fixation and anti-infection properties.  COLLOIDS AND SURFACES B-BIOINTERFACES,  219  (112817).  [PMID:36084513]
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22. Jia Xu, Menglin Shi, Guilun He, Shuyan Chi, Shuang Zhang, Junming Cao, Beiping Tan, Shiwei Xie.  (2022)  The effects of a mixture of antibiotics on the intestinal microbiota and hepatic lipid deposition in hybrid grouper fed bile acids diet.  Aquaculture Reports,  24  (101169).  [PMID:]
23. Yang Liu, Xin Zhang, Shuo Chen, Jiazhong Wang, Shuo Yu, Yiming Li, Meng Xu, Harouna Aboubacar, Junhui Li, Tao Shan, Jixin Wang, Gang Cao.  (2022)  Gut-derived lipopolysaccharide promotes alcoholic hepatosteatosis and subsequent hepatocellular carcinoma by stimulating neutrophil extracellular traps through toll-like receptor 4.  Clinical and Molecular Hepatology,  28  (3): ( 522–539).  [PMID:35508957]
24. Qianqian Yao, Linlin Fan, Nan Zheng, Christophe Blecker, Véronique Delcenserie, Huiying Li, Jiaqi Wang.  (2022)  2′-Fucosyllactose Ameliorates Inflammatory Bowel Disease by Modulating Gut Microbiota and Promoting MUC2 Expression.  Frontiers in Nutrition,  9  (822020).  [PMID:35252301]
25. Leilei Sun, Sisi Shi, Hongchao Geng, Yao Huang, Yan Qiao, Jie Song, Lan Yang, Craig A. Grimes, Xinxin Feng, Qingyun Cai.  (2021)  NaGdF4:Nd@NaGdF4 Core-Shell Down-Conversion Nanoparticles as NIR-II Fluorescent Probes for Targeted Imaging of Bacteria.  ACS Applied Nano Materials,  4  (10): (11231–11238).  [PMID:]
26. Su Jiyan, Chen Xiaohong, Xiao Yuanjie, Li Dan, Li Muxia, Li Hongfu, Huang Jiangjian, Lai Zhengquan, Su Ziren, Xie Yizhen, Zhu Dajiang, Chen Qianjun, Lu Hai, He Jingjin, Xia Chenglai.  (2021)  Bruceae Fructus Oil Inhibits Triple-Negative Breast Cancer by Restraining Autophagy: Dependence on the Gut Microbiota-Mediated Amino Acid Regulation.  Frontiers in Pharmacology,  12    [PMID:34658867]
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29. Chen Guanhua, Yang Guotai, Wang Yutong, Deng Mei, Wang Zhengzheng, Aguilar Zoraida P., Xu Hengyi.  (2021)  Antibiotic-Based Magnetic Nanoprobes Combined with mPCR for Simultaneous Detection of Staphylococcus aureus and Bacillus cereus.  Food Analytical Methods,  14  (9): (1964-1976).  [PMID:]
30. Cong Wu, Xinghui Wei, Kang Zhao, Junyi Jiang, Mengzhen Jiao, Junhua Cheng, Zhen Tang, Zheng Guo, Yufei Tang.  (2021)  Novel dam-like effect based on piezoelectric energy conversion for drug sustained release of drug-loaded TiO2 @ BaTiO3 coaxial nanotube coating.  CERAMICS INTERNATIONAL,  47  (17550).  [PMID:]
31. Xiaoyan Feng, Xiangyu Meng, Fangbin Xiao, Zoraida P. Aguilar, Hengyi Xu.  (2021)  Vancomycin-dendrimer based multivalent magnetic separation nanoplatforms combined with multiplex quantitative PCR assay for detecting pathogenic bacteria in human blood.  TALANTA,  225  (121953).  [PMID:33592708]
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35. Xing He, Ziyan Zhou, Zhuo Han, Yang Zeng, Xiaojie Chen, Jiacan Su.  (2019)  Mechanism of Controlled Release of Vancomycin from Crumpled Graphene Oxides.  ACS Omega,  4  (7): (12252–12258).  [PMID:31460341]
36. Bing Cao, Fengfeng Xiao, Da Xing, Xianglong Hu.  (2018)  Polyprodrug Antimicrobials: Remarkable Membrane Damage and Concurrent Drug Release to Combat Antibiotic Resistance of Methicillin-Resistant Staphylococcus aureus.  Small,  14  (41): (1802008).  [PMID:30118562]
37. Li Qun Xu, Yan Biao Liao, Ning Ning Li, Yi Jian Li, Jie Yu Zhang, Yun Bing Wang, Xue Feng Hu, Chang Ming Li.  (2018)  Vancomycin-assisted green synthesis of reduced graphene oxide for antimicrobial applications.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  514  (733).  [PMID:29316529]
38. Ling Gui Ning, Shuai Wang, Xue Feng Hu, Chang Ming Li, Li Qun Xu.  (2017)  Vancomycin-conjugated polythiophene for the detection and imaging of Gram-positive bacteria.  Journal of Materials Chemistry B,  5  (44): (8814-8820).  [PMID:32264274]
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