Vilazodone - ≥98%, high purity , CAS No.163521-12-8, Agonist of 5-HT 1A receptor;Agonist of 5-HT 4 receptor;Agonist of D 2 receptor;Agonist of D 3 receptor;Agonist of H 1 receptor;Inhibitor of SERT
Vilazodone - ≥98%, high purity , CAS No.163521-12-8, Agonist of 5-HT 1A receptor;Agonist of 5-HT 4 receptor;Agonist of D 2 receptor;Agonist of D 3 receptor;Agonist of H 1 receptor;Inhibitor of SERT
Vilazodone (EMD 68843; SB 659746A; 5-{4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl}-benzofuran-2-carboxamide hydrochloride) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
AGONIST, INHIBITOR
Mechanism of action
Agonist of 5-HT 1A receptor;Agonist of 5-HT 4 receptor;Agonist of D 2 receptor;Agonist of D 3 receptor;Agonist of H 1 receptor;Inhibitor of SERT
Product Description
Vilazodone is an inhibitor of ST (serotonin transporter and uptake) (IC50 = 0.5 nM) and SR-1A activator (partial agonist) (IC50 = 0.2 nM; IA = ~60-70%). An inhibitor of ST and activator of SR-1A
1.Dawson LA, Watson JM. (2009) Vilazodone: a 5-HT1A receptor agonist/serotonin transporter inhibitor for the treatment of affective disorders.. CNS Neurosci Ther, 15 (2):(107-17). [PMID:19499624]
2.Heinrich T, Böttcher H, Gericke R, Bartoszyk GD, Anzali S, Seyfried CA, Greiner HE, Van Amsterdam C. (2004) Synthesis and structure--activity relationship in a class of indolebutylpiperazines as dual 5-HT(1A) receptor agonists and serotonin reuptake inhibitors.. J Med Chem, 47 (19):(4684-92). [PMID:15341484]
3.Hughes ZA, Starr KR, Langmead CJ, Hill M, Bartoszyk GD, Hagan JJ, Middlemiss DN, Dawson LA. (2005) Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone.. Eur J Pharmacol, 510 (1-2):(49-57). [PMID:15740724]
4.Zhu XY, Etukala JR, Eyunni SV, Setola V, Roth BL, Ablordeppey SY. (2012) Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants.. Eur J Med Chem, 53 (3):(124-32). [PMID:22520153]
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E1712149