Vimirogant (VTP-43742) hydrochloride is a potent, selective, and orally active RORγt inhibitor ( K i =3.5 nM; IC 50 =17 nM). Vimirogant hydrochloride exhibits >1000-fold selectivity versus the RORα and RORβ isotypes. Vimirogant hydrochloride inhibits Th17
In Vitro:Vimirogant hydrochloride inhibits the secretion of IL-17A from activated hPBMCs (IC 50 =18 nM) and human whole blood (IC 50 =192 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo:In the MOG35-55/CFA immunized mouse EAE model, Vimirogant hydrochloride (p.o.) significantly suppresses clinical symptoms, demyelination and mRNA expression of multiple inflammatory markers in the spinal cord. MCE has not independently confirmed the
Biological Activity:Vimirogant (VTP-43742) hydrochloride is a potent, selective, and orally active RORγt inhibitor ( K i =3.5 nM; IC 50 =17 nM). Vimirogant hydrochloride exhibits >1000-fold selectivity versus the RORα and RORβ isotypes. Vimirogant hydrochloride inhibits Th17
