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voclosporin, CAS No.515814-01-4, Inhibitor of peptidylprolyl isomerase A

  • Moligand™
Features and benefits
    Item Number
    rp175393
    Grouped product items
    SKUSizeAvailabilityPrice Qty
    rp175393-500μg
    500μg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $1,334.90
    rp175393-1mg
    1mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $2,334.90

    Basic Description

    Product Namevoclosporin, CAS No.515814-01-4
    SynonymsVoclosporin|515814-01-4|Lupkynis|Luveniq|ISAtx-247|ISA-247|Voclosporin [USAN]|ISA247|ISATX247|trans-ISA 247|ISA 247|LX211|LX-211|ISATX 247|R 1524|R-1524|UNII-2PN063X6B1|2PN063X6B1|515814-00-3|E-ISA247|ISA(TX)247|(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-e
    GradeMoligand™
    Action TypeINHIBITOR
    Mechanism of actionInhibitor of peptidylprolyl isomerase A

    Associated Targets

    PPIA Tclin Peptidyl-prolyl cis-trans isomerase A 0 Activities

    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    Product Specifications

    CAS515814-01-4

    Certificates

    Certificate of Analysis(COA)

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    Genetic information

    Alternate NamesVoclosporin|515814-01-4|Lupkynis|Luveniq|ISAtx-247|ISA-247|Voclosporin [USAN]|ISA247|ISATX247|trans-ISA 247|ISA 247|LX211|LX-211|ISATX 247|R 1524|R-1524|UNII-2PN063X6B1|2PN063X6B1|515814-00-3|E-ISA247|ISA(TX)247|(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-e
    Reference
    • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
    • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
    • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
    • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
    • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
    • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
    • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
    • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
    • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
    • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

    Related Documents

    References

    1. Abel MD, Aspeslet LJ, Freitag DG, Naicker S, Trepanier DJ, Kneteman NM, Foster RT, Yatscoff RW.  (2001)  ISATX247: a novel calcineurin inhibitor..  J Heart Lung Transplant,  20  (2): (161).  [PMID:11250240]
    2. Aspeslet L, Freitag D, Trepanier D, Abel M, Naicker S, Kneteman N, Foster R, Yatscoff R.  (2001)  ISA(TX)247: a novel calcineurin inhibitor..  Transplant Proc,  33  (1-2): (1048-51).  [PMID:11267185]
    3. Bîrsan T, Dambrin C, Freitag DG, Yatscoff RW, Morris RE.  (2005)  The novel calcineurin inhibitor ISA247: a more potent immunosuppressant than cyclosporine in vitro..  Transpl Int,  17  (12): (767-71).  [PMID:15827754]
    4. Chan CL, Jones RL, Lau HY.  (2007)  ISA 247: trans-ISA 247, trans-R 1524, ISA(TX)247, ISAtx 247, ISATx247, LX 211, LX211, R 1524, R-1524..  Drugs R D,  (2): (103-12).  [PMID:17324008]
    5. Kuglstatter A, Mueller F, Kusznir E, Gsell B, Stihle M, Thoma R, Benz J, Aspeslet L, Freitag D, Hennig M.  (2011)  Structural basis for the cyclophilin A binding affinity and immunosuppressive potency of E-ISA247 (voclosporin)..  Acta Crystallogr D Biol Crystallogr,  67  (Pt 2): (119-23).  [PMID:21245533]
    6. Li Y, Palmisano M, Sun D, Zhou S.  (2020)  Pharmacokinetic Disposition Difference Between Cyclosporine and Voclosporin Drives Their Distinct Efficacy and Safety Profiles in Clinical Studies..  Clin Pharmacol,  12  (3): (83-96).  [PMID:32669879]

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