Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab176075-100μg | 100μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $79.90 | |
| Ab176075-1mg | 1mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $389.90 | |
| Ab176075-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $959.90 | |
| Ab176075-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,529.90 |
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Vorsetuzumab (anti-CD70) - Primary antibody, specific to CD70, >95%, high purity, Human IgG1 |
|---|---|
| Synonyms | CD 27L antibody; CD 70 antibody; CD27 L antibody; CD27 LG antibody; CD27 ligand antibody; CD27-L antibody; CD27L antibody; CD27LG antibody; CD70 antibody; CD70 antigen antibody; CD70 molecule antibody; CD70_HUMAN antibody; Ki 24 antigen antibody; Ki24 ant |
| Specifications & Purity | ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot |
| Specificity | CD70 |
| Conjugation | Unconjugated |
| Grade | Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | BINDING AGENT |
| Mechanism of action | BINDING AGENT of CD70 antigen binding agent |
| Product Description | Vorsetuzumab (anti-CD70) is a human anti-CD70 antibody. Vorsetuzumab (anti-CD70) enhances macrophage-related phagocytosis of renal carcinoma cells, shows inhibitory efficacy against Burkitt’s lymphoma. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 27.1 kDa (Light Chain) & 52.6 kDa (Heavy Chain), under reducing conditions; 180.8 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Form | Liquid |
| Concentration | Lot by Lot |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
| CAS | 1165740-62-4 |
Vorsetuzumab (anti-CD70) (Ab176075) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling CD70 (red) with Vorsetuzumab (anti-CD70) (Ab176075). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Vorsetuzumab (anti-CD70) (Ab176075) - SEC
The purity of Vorsetuzumab (anti-CD70) (Ab176075) is more than 95% verified by HPLC.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ23F1001277 | Certificate of Analysis | Oct 13, 2023 | Ab176075 |
| ZJ23F1001278 | Certificate of Analysis | Oct 13, 2023 | Ab176075 |
| 1. Bowman, M R MR and 5 more authors.. (1994) The cloning of CD70 and its identification as the ligand for CD27.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:8120384] |
| 2. Goodwin, R G RG and 9 more authors.. (1993) Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor.. Cell, (7): [PMID:8387892] |
| 3. Izawa, Kazushi K and 15 more authors.. (2017) Inherited CD70 deficiency in humans reveals a critical role for the CD70-CD27 pathway in immunity to Epstein-Barr virus infection.. The Journal of experimental medicine, [PMID:28011863] |
| 4. Abolhassani, Hassan H and 32 more authors.. (2017) Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency.. The Journal of experimental medicine, [PMID:28011864] |
