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Vortioxetine - ≥98%, high purity , CAS No.508233-74-7, Agonist of 5-HT 1A receptor;Agonist of 5-HT 1B receptor;Antagonist of 5-HT 1D receptor;Antagonist of 5-HT 2A receptor;Antagonist of 5-HT 3A;Antagonist of 5-HT 5A receptor;Antagonist of 5-HT 6 receptor;Antagonist of 5-HT 7 receptor;Inhibitor of SERT

Moligand™
≥98%

CAS#: 508233-74-7
Formula: C₁₈H₂₂N₂S
Molecular Weight: 298.45
EC Number: 823-919-6
PubChem CID: 9966051
PubChem SID: 488196483

Item Number

V125545

Grouped product items
SKU	Size	Availability	Price
V125545-10mg	10mg	In stock	$53.90
V125545-50mg	50mg	In stock	$118.90
V125545-250mg	250mg	In stock	$535.90
V125545-1g	1g	In stock	$706.90

View related series

5-HT1A receptor Agonist 5-HT1B receptor Agonist 5-HT1D receptor Antagonist 5-HT2A receptor Antagonist 5-HT3A Antagonist 5-HT5A receptor Antagonist 5-HT6 receptor Antagonist 5-HT7 receptor Antagonist SERT Inhibitor

Basic Description

Synonyms	VORTIOXETINE\|508233-74-7\|1-(2-((2,4-Dimethylphenyl)thio)phenyl)piperazine\|Lu AA21004\|1-{2-[(2,4-dimethylphenyl)sulfanyl]phenyl}piperazine\|Vortioxetine free base\|vortioxetina\|vortioxetinum\|1-[2-(2,4-dimethylphenyl)sulfanylphenyl]piperazine\|UNII-3O2K1S3WQV\|
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST, ANTAGONIST, INHIBITOR
Mechanism of action	Agonist of 5-HT 1A receptor;Agonist of 5-HT 1B receptor;Antagonist of 5-HT 1D receptor;Antagonist of 5-HT 2A receptor;Antagonist of 5-HT 3A;Antagonist of 5-HT 5A receptor;Antagonist of 5-HT 6 receptor;Antagonist of 5-HT 7 receptor;Inhibitor of SERT
Product Description	Vortioxetine (Lu AA21004) is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively. IC50 Value: 15nM (5-HT1A); 33nM (5-HT1B); 3.7nM(5-HT3A); 19nM (5-HT7); 1.6 nM(SERT) Target: 5-HT receptor

Associated Targets

SLC6A4 Tclin Sodium-dependent serotonin transporter 1 Activities

Discover Target: SLC6A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR1B Tclin 5-hydroxytryptamine receptor 1B 1 Activities

Discover Target: HTR1B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR5A Tchem 5-hydroxytryptamine receptor 5A 1 Activities

Discover Target: HTR5A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR2A Tclin 5-hydroxytryptamine receptor 2A 1 Activities

Discover Target: HTR2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR7 Tclin 5-hydroxytryptamine receptor 7 5 Activities

Discover Target: HTR7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR1D Tclin 5-hydroxytryptamine receptor 1D 1 Activities

Discover Target: HTR1D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR1A Tclin 5-hydroxytryptamine receptor 1A 5 Activities

Discover Target: HTR1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR3A Tclin 5-hydroxytryptamine receptor 3A 1 Activities

Discover Target: HTR3A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR6 Tchem 5-hydroxytryptamine receptor 6 1 Activities

Discover Target: HTR6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488196483
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488196483
IUPAC Name	1-[2-(2,4-dimethylphenyl)sulfanylphenyl]piperazine
INCHI	InChI=1S/C18H22N2S/c1-14-7-8-17(15(2)13-14)21-18-6-4-3-5-16(18)20-11-9-19-10-12-20/h3-8,13,19H,9-12H2,1-2H3
InChi Key	YQNWZWMKLDQSAC-UHFFFAOYSA-N
Canonical SMILES	CC1=CC(=C(C=C1)SC2=CC=CC=C2N3CCNCC3)C
Isomeric SMILES	CC1=CC(=C(C=C1)SC2=CC=CC=C2N3CCNCC3)C
Alternate CAS	508233-74-7
PubChem CID	9966051
MeSH Entry Terms	1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine;brintellix;Lu AA21004;Lu-AA21004;LuAA21004;vortioxetine;vortioxetine hydrobromide
Molecular Weight	298.45

PubChem CID

Wikipedia

CAS Registry No.

ChEMBL Ligand

PEP

DrugCentral Ligand

GPCRdb Ligand

PubChem SID

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

6 results found

Lot Number	Certificate Type	Date	Item
L1713086	Certificate of Analysis	May 10, 2023	V125545
C2304106	Certificate of Analysis	Feb 13, 2023	V125545
C2304107	Certificate of Analysis	Feb 13, 2023	V125545
C2304108	Certificate of Analysis	Feb 13, 2023	V125545
C2304111	Certificate of Analysis	Feb 13, 2023	V125545
E2315528	Certificate of Analysis	Feb 13, 2023	V125545

Safety and Hazards(GHS)

Pictogram(s)	GHS08
Signal	Warning
Hazard Statements	H373:Causes damage to organs through prolonged or repeated exposure H361:Suspected of damaging fertility or the unborn child H371:May cause damage to organs
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. P308+P316:IF exposed or concerned: Get emergency medical help immediately. P319:Get medical help if you feel unwell.

References

1. Bang-Andersen B, Ruhland T, Jørgensen M, Smith G, Frederiksen K, Jensen KG, Zhong H, Nielsen SM, Hogg S, Mørk A et al.. (2011) Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder.. J Med Chem, 54 (9): (3206-21). [PMID:21486038]
2. Talmon M, Rossi S, Pastore A, Cattaneo CI, Brunelleschi S, Fresu LG. (2018) Vortioxetine exerts anti-inflammatory and immunomodulatory effects on human monocytes/macrophages.. Br J Pharmacol, 175 (1): (113-124). [PMID:29057467]

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