VT104 , CAS No.2417718-25-1

Item Number

V646898

Grouped product items
SKU	Size	Availability	Price
V646898-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$90.90
V646898-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$310.90
V646898-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$503.90

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Basic Description

Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	VT104 is a potent and orally active YAP/TAZ inhibitor. VT104 prevents palmitoylation of endogenous TEAD1 and TEAD3 proteins. VT104 can be used in research of cancer. In Vitro VT104 (0-1000 nM) inhibits proliferation of NF2 mutant/defective cell line. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo VT104 (0.3-3 mg/kg; p.o.; NCI-H226-tumor bearing mice) blocks growth of NF2-deficient mesothelioma xenografts . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: NCI-H226-tumor bearing mice Dosage: 0.3, 1, and 3 mg/kg Administration: Oral administration Result: Blocked NCI-H226 tumor growth in mice in dose-dependent manner. Form:Solid

Canonical SMILES

O=C(C1=CC=C2C(C3=CC=C(C(F)(F)F)C=C3)=CC=CC2=C1)N[C@H](C4=NC=CC=C4)C

Molecular Weight

420.43

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Basic Description