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VU 0134992 - ≥98%(HPLC), high purity , CAS No.755002-90-5, Channel blocker of K ir4.1

Moligand™
≥98%(HPLC)

CAS#: 755002-90-5
Formula: C₂₀H₃₁BrN₂O₂
Molecular Weight: 411.38
PubChem CID: 1319582

Item Number

V288022

Grouped product items
SKU	Size	Availability	Price
V288022-5mg	5mg	In stock	$108.90
V288022-10mg	10mg	In stock	$166.90
V288022-25mg	25mg	In stock	$374.90
V288022-50mg	50mg	In stock	$698.90
V288022-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,256.90

Kir4.1 blocker

View related series

Kir4.1 Channel blocker

Basic Description

Synonyms	2-(2-Bromo-4-isopropylphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Kir4.1 potassium channel blocker (IC50= 0.97 μM). Displays 10-fold selectivity for Kir4.1 over Kir4.1/5.1 concatemeric channels and >30-fold selectivity over Kir1.1, 2.1 and 2.2. Increases urine output and urinary Na+and K+excretion in volume-loaded rats.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	CHANNEL BLOCKER
Mechanism of action	Channel blocker of K ir4.1
Product Description	VU0134992 is a selective inward rectifier potassium (Kir) channel Kir4.1 blocker with IC50 of 0.97 µM.

Associated Targets

SMAD3 Tchem Mothers against decapentaplegic homolog 3 0 Activities

Discover Target: SMAD3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLI Tchem DNA polymerase iota 0 Activities

Discover Target: POLI

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Discover Target: TDP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GLP1R Tclin Glucagon-like peptide 1 receptor 0 Activities

Discover Target: GLP1R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNJ10 Tbio ATP-sensitive inward rectifier potassium channel 10 0 Activities

Discover Target: KCNJ10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-(2-bromo-4-propan-2-ylphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide
INCHI	InChI=1S/C20H31BrN2O2/c1-13(2)14-7-8-17(16(21)9-14)25-12-18(24)22-15-10-19(3,4)23-20(5,6)11-15/h7-9,13,15,23H,10-12H2,1-6H3,(H,22,24)
InChi Key	OTTDLWFVHQYRDA-UHFFFAOYSA-N
Canonical SMILES	CC(C)C1=CC(=C(C=C1)OCC(=O)NC2CC(NC(C2)(C)C)(C)C)Br
Isomeric SMILES	CC(C)C1=CC(=C(C=C1)OCC(=O)NC2CC(NC(C2)(C)C)(C)C)Br
PubChem CID	1319582
Molecular Weight	411.38

PubChem CID

1319582

ChEMBL Ligand

CHEMBL1871911

CAS Registry No.

755002-90-5

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
A2219673	Certificate of Analysis	Dec 13, 2021	V288022
A2219687	Certificate of Analysis	Dec 13, 2021	V288022
A2219688	Certificate of Analysis	Dec 13, 2021	V288022
A2219711	Certificate of Analysis	Dec 13, 2021	V288022
A2219712	Certificate of Analysis	Dec 13, 2021	V288022

References

1. Kharade SV, Kurata H, Bender AM, Blobaum AL, Figueroa EE, Duran A, Kramer M, Days E, Vinson P, Flores D et al.. (2018) Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992.. Mol Pharmacol, 94 (2): (926-937). [PMID:29895592]

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