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VU 0285683 - ≥98%(HPLC), high purity , CAS No.327056-22-4, Allosteric modulator of mGlu 5 receptor
Negative allosteric modulator of mGlu5receptors
Basic Description Synonyms 3-Fluoro-5-[3-(2-pyridinyl)-1,2,4-oxadiazol-5-yl]-benzonitrile；3-fluoro-5-(3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl)benzonitrile； Specifications & Purity Moligand™, ≥98%(HPLC) Biochemical and Physiological Mechanisms Negative allosteric modulator of mGlu5receptors. Displays high affinity for the MPEP binding site; acts as a full antagonist and blocks the glutamate response to mGlu5(IC50= 24.4 nM). Selective for mGlu5over mGlu1, mGlu3and mGlu4. Exhibits anxiolytic acti Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ALLOSTERIC MODULATOR Mechanism of action Allosteric modulator of mGlu 5 receptor
Names and Identifiers Pubchem Sid 488196325 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488196325 IUPAC Name 3-fluoro-5-(3-pyridin-2-yl-1,2,4-oxadiazol-5-yl)benzonitrile INCHI InChI=1S/C14H7FN4O/c15-11-6-9(8-16)5-10(7-11)14-18-13(19-20-14)12-3-1-2-4-17-12/h1-7H InChi Key GELAFISMURFRCA-UHFFFAOYSA-N Canonical SMILES C1=CC=NC(=C1)C2=NOC(=N2)C3=CC(=CC(=C3)C#N)F Isomeric SMILES C1=CC=NC(=C1)C2=NOC(=N2)C3=CC(=CC(=C3)C#N)F PubChem CID 9816778 Molecular Weight 266.23
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 13.31, Max Conc. mM: 50; Solvent:ethanol, Max Conc. mg/mL: 6.66, Max Conc. mM: 25
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