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VU 0357017 Hydrochloride - ≥98% (HPLC), high purity , CAS No.1135242-13-5
Positive allosteric modulator of M1receptors
Basic Description Synonyms EX-A1757 | N-ACETYL PROCAINAMIDE(<30%) | Ethyl 4-{[2-(2-methylbenzamido)ethyl]amino}piperidine-1-carboxylate--hydrogen chloride (1/1) | J-002978 | VU0357017 | 4-[[2-[(2-methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester, monohydrochl Specifications & Purity ≥98%(HPLC) Biochemical and Physiological Mechanisms Positive allosteric modulator of muscarinic M1receptors (EC50= 198 nM). Displays no activity at M2-M5at concentrations up to 30μM. Potentiates NMDA receptor currents in hippocampal neurons; activity reverses cognitive decifits in a rodent model of hippoca Storage Temp Store at 2-8°C Shipped In Wet ice Product Description VU0357017 hydrochloride (CID-25010775) is a potent, selective and brain-penetrant allosteric agonist of M1 muscarinic acetylcholine receptor, with an EC50 of 477 nM. VU0357017 hydrochloride is highly selective for M1 and has no activity at M2-M5 up to the highest concentrations tested (30 μM). VU0357017 hydrochloride can be used for the research of Alzheimer’s disease and schizophrenia。
Associated Targets(Human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers Pubchem Sid 488200737 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488200737 IUPAC Name ethyl 4-[2-[(2-methylbenzoyl)amino]ethylamino]piperidine-1-carboxylate;hydrochloride INCHI InChI=1S/C18H27N3O3.ClH/c1-3-24-18(23)21-12-8-15(9-13-21)19-10-11-20-17(22)16-7-5-4-6-14(16)2;/h4-7,15,19H,3,8-13H2,1-2H3,(H,20,22);1H InChi Key XKJQVUIXSBOCPP-UHFFFAOYSA-N Canonical SMILES CCOC(=O)N1CCC(CC1)NCCNC(=O)C2=CC=CC=C2C.Cl Isomeric SMILES CCOC(=O)N1CCC(CC1)NCCNC(=O)C2=CC=CC=C2C.Cl WGK Germany 2 PubChem CID 25010775 Molecular Weight 369.89
Chemical and Physical Properties Solubility Solvent:water, Max Conc. mg/mL: 9.25, Max Conc. mM: 25; Solvent:DMSO, Max Conc. mg/mL: 1.85, Max Conc. mM: 5 Sensitivity Moisture sensitive
Safety and Hazards(GHS) Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
H302: Harmful if swallowed
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
WGK Germany 2
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