VU 0357017 Hydrochloride - ≥98% (HPLC), high purity , CAS No.1135242-13-5

Item Number

V134258

• Synonyms: VU 0357017 Hydrochloride|1135242-13-5|vu0357017 hydrochloride|VU0357017 HCl|VU0357017|VU0357017 (hydrochloride)|ethyl 4-(2-(2-methylbenzamido)ethylamino)piperidine-1-carboxylate hydrochloride|4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxyl
• Specifications & Purity: ≥98%(HPLC)
• Biochemical and Physiological Mechanisms: Positive allosteric modulator of muscarinic M1receptors (EC50= 198 nM). Displays no activity at M2-M5at concentrations up to 30μM. Potentiates NMDA receptor currents in hippocampal neurons; activity reverses cognitive decifits in a rodent model of hippoca
• Storage Temp: Store at 2-8°C
• Shipped In: Wet ice

Product Description

VU0357017 hydrochloride (CID-25010775) is a potent, selective and brain-penetrant allosteric agonist of M1 muscarinic acetylcholine receptor, with an EC50 of 477 nM. VU0357017 hydrochloride is highly selective for M1 and has no activity at M2-M5 up to the highest concentrations tested (30 μM). VU0357017 hydrochloride can be used for the research of Alzheimer’s disease and schizophrenia。