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VU 0357121 - ≥98%, high purity , CAS No.433967-28-3, Allosteric modulator of mGlu 5 receptor

  • Moligand™
  • ≥98%
Item Number
V129515
Grouped product items
SKUSizeAvailabilityPrice Qty
V129515-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$105.90
V129515-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$450.90
V129515-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$811.90
V129515-250mg
250mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,826.90

Positive allosteric modulator of mGlu5receptors

Basic Description

SynonymsVU 0357121|433967-28-3|4-butoxy-N-(2,4-difluorophenyl)benzamide|VU0357121|CHEMBL2151790|VU-0357121(VU0357121)|VU-0357121|Cambridge id 6991768|MLS006011793|GTPL6399|DTXSID10367833|EX-A195|HMS3656J10|HMS3884B18|BCP04788|BDBM50392425|MFCD03243692|s2795|STK14
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsPositive allosteric modulator of mGlu5receptors (EC50= 33 nM). Binds to a site distinct from that bound byMPEP.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeALLOSTERIC MODULATOR
Mechanism of actionAllosteric modulator of mGlu 5 receptor
Note50mg、250mg、10mg卖完停产,不再备货
Product Description

VU0357121 is a novel positive allosteric modulator (PAM) of mGlu5 with EC50 of 33 nM, is inactive or very weakly antagonizing at other mGlu receptor subtypes.
A novel allosteric modulator of mGluR-5 receptors

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRM5 Tchem Metabotropic glutamate receptor 5 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 4-butoxy-N-(2,4-difluorophenyl)benzamide
INCHI InChI=1S/C17H17F2NO2/c1-2-3-10-22-14-7-4-12(5-8-14)17(21)20-16-9-6-13(18)11-15(16)19/h4-9,11H,2-3,10H2,1H3,(H,20,21)
InChi Key AHCYOTLTLQTPSU-UHFFFAOYSA-N
Canonical SMILES CCCCOC1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)F)F
Isomeric SMILES CCCCOC1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)F)F
WGK Germany 3
PubChem CID 2296132
Molecular Weight 305.32

Certificates

Certificate of Analysis(COA)

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2 results found

Lot NumberCertificate TypeDateItem
E1712145Certificate of AnalysisJan 16, 2023 V129515
K2313006Certificate of AnalysisJan 16, 2023 V129515

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 30.53, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 30.53, Max Conc. mM: 100

Safety and Hazards(GHS)

Pictogram(s) GHS09
Hazard Statements

H410:Very toxic to aquatic life with long lasting effects

Precautionary Statements

P273:Avoid release to the environment.

P501:Dispose of contents/container to ...

WGK Germany 3

Related Documents

Solution Calculators