Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
V129515-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $105.90 | |
V129515-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $450.90 | |
V129515-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $811.90 | |
V129515-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,826.90 |
Positive allosteric modulator of mGlu5receptors
Synonyms | VU 0357121|433967-28-3|4-butoxy-N-(2,4-difluorophenyl)benzamide|VU0357121|CHEMBL2151790|VU-0357121(VU0357121)|VU-0357121|Cambridge id 6991768|MLS006011793|GTPL6399|DTXSID10367833|EX-A195|HMS3656J10|HMS3884B18|BCP04788|BDBM50392425|MFCD03243692|s2795|STK14 |
---|---|
Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Positive allosteric modulator of mGlu5receptors (EC50= 33 nM). Binds to a site distinct from that bound byMPEP. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ALLOSTERIC MODULATOR |
Mechanism of action | Allosteric modulator of mGlu 5 receptor |
Note | 50mg、250mg、10mg卖完停产,不再备货 |
Product Description | VU0357121 is a novel positive allosteric modulator (PAM) of mGlu5 with EC50 of 33 nM, is inactive or very weakly antagonizing at other mGlu receptor subtypes. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
IUPAC Name | 4-butoxy-N-(2,4-difluorophenyl)benzamide |
---|---|
INCHI | InChI=1S/C17H17F2NO2/c1-2-3-10-22-14-7-4-12(5-8-14)17(21)20-16-9-6-13(18)11-15(16)19/h4-9,11H,2-3,10H2,1H3,(H,20,21) |
InChi Key | AHCYOTLTLQTPSU-UHFFFAOYSA-N |
Canonical SMILES | CCCCOC1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)F)F |
Isomeric SMILES | CCCCOC1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)F)F |
WGK Germany | 3 |
PubChem CID | 2296132 |
Molecular Weight | 305.32 |
CAS Registry No. | 433967-28-3 |
---|---|
PubChem CID | 2296132 |
ChEMBL Ligand | CHEMBL2151790 |
GPCRdb Ligand | VU0357121 |
Enter Lot Number to search for COA:
Solubility | Solvent:DMSO, Max Conc. mg/mL: 30.53, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 30.53, Max Conc. mM: 100 |
---|
Pictogram(s) | GHS09 |
---|---|
Hazard Statements | H410:Very toxic to aquatic life with long lasting effects |
Precautionary Statements | P273:Avoid release to the environment. P501:Dispose of contents/container to ... |
WGK Germany | 3 |