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VU 0361737 - ≥98%(HPLC), high purity , CAS No.1161205-04-4, Allosteric modulator of mGlu 4 receptor

Moligand™
≥98%(HPLC)

CAS#: 1161205-04-4
Formula: C₁₃H₁₁ClN₂O₂
Molecular Weight: 262.69
MDL number: MFCD16618402
PubChem CID: 44191096

Item Number

V129527

Grouped product items
SKU	Size	Availability	Price
V129527-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$82.90
V129527-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$284.90
V129527-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,282.90

Selective positive allosteric modulator of mGlu4receptors

View related series

mGlu4 receptor Allosteric modulator

Basic Description

Synonyms	1161205-04-4\|VU 0361737\|VU0361737\|N-(4-chloro-3-methoxyphenyl)picolinamide\|N-(4-chloro-3-methoxyphenyl)pyridine-2-carboxamide\|N-(4-CHLORO-3-METHOXYPHENYL)-2-PYRIDINECARBOXAMIDE\|C13H11ClN2O2\|CHEMBL562551\|2-Pyridinecarboxamide, N-(4-chloro-3-methoxyphenyl)-
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Selective positive allosteric modulator at mGlu4receptors (EC50values are 240 and 110 nM at human and rat receptors respectively). Inactive at mGlu1, mGlu2, mGlu3, mGlu6and mGlu7receptors and displays weak activity at mGlu5and mGlu8receptors. Brain penet
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of mGlu 4 receptor
Note	卖完停产，不再备货
Product Description	VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively, displays weak activity at mGlu5 and mGlu8 receptors, is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors, can penetrate into CNS. a selective positive allosteric modulator at mGluR-4

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

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CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

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CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

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HDAC6 Tclin Histone deacetylase 6 0 Activities

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GRM1 Tchem Metabotropic glutamate receptor 1 0 Activities

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GRM2 Tchem Metabotropic glutamate receptor 2 0 Activities

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GRM4 Tchem Metabotropic glutamate receptor 4 3 Activities

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GRM5 Tchem Metabotropic glutamate receptor 5 0 Activities

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GRM7 Tchem Metabotropic glutamate receptor 7 0 Activities

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GRM8 Tchem Metabotropic glutamate receptor 8 0 Activities

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GRM3 Tchem Metabotropic glutamate receptor 3 0 Activities

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Names and Identifiers

IUPAC Name	N-(4-chloro-3-methoxyphenyl)pyridine-2-carboxamide
INCHI	InChI=1S/C13H11ClN2O2/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H,1H3,(H,16,17)
InChi Key	ARYUXFNGXHNNDM-UHFFFAOYSA-N
Canonical SMILES	COC1=C(C=CC(=C1)NC(=O)C2=CC=CC=N2)Cl
Isomeric SMILES	COC1=C(C=CC(=C1)NC(=O)C2=CC=CC=N2)Cl
WGK Germany	3
PubChem CID	44191096
Molecular Weight	262.69

CAS Registry No.

PubChem CID

ChEMBL Ligand

GPCRdb Ligand

Certificates

Certificate of Analysis(COA)

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1 results found

Lot Number	Certificate Type	Date	Item
E1712143	Certificate of Analysis	Jan 16, 2023	V129527

Hazard Statements

H319:Causes serious eye irritation

H302:Harmful if swallowed

Precautionary Statements

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

WGK Germany

References

1. Engers DW, Niswender CM, Weaver CD, Jadhav S, Menon UN, Zamorano R, Conn PJ, Lindsley CW, Hopkins CR. (2009) Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs).. J Med Chem, 52 (14): (4115-8). [PMID:19469556]

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