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VU 0463271 - ≥98%(HPLC), high purity , CAS No.1391737-01-1

  • ≥98%(HPLC)
Item Number
V288619
Grouped product items
SKUSizeAvailabilityPrice Qty
V288619-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$68.90
V288619-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$115.90
V288619-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$258.90
V288619-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$416.90
V288619-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$616.90

Potent and selective KCC2 inhibitor

View related series
Potassium Channel

Basic Description

SynonymsVU0463271;N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide, N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]-acetamide, N-Cyclopropyl-N-(4-methylthiazol-2-yl)-2-(6-phenylpyridazin-3-ylthio)acetamide;N
Specifications & Purity≥98%(HPLC)
Biochemical and Physiological MechanismsVU0463271 is a potent and selective potassium-chloride cotransporter 2 (KCC2) inhibitor that displays greatly enhanced potency than its structural analogs VU0255011 (ML077) & VU0240511 (IC50 = 61, 537, and 568 nM, respectively). VU0463271 exhibits much re
Storage TempStore at -20°C
Shipped InIce chest + Ice pads

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLC12A5 Tchem Solute carrier family 12 member 5 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLC12A2 Tclin Solute carrier family 12 member 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name N-cyclopropyl-N-(4-methyl-1,3-thiazol-2-yl)-2-(6-phenylpyridazin-3-yl)sulfanylacetamide
INCHI InChI=1S/C19H18N4OS2/c1-13-11-26-19(20-13)23(15-7-8-15)18(24)12-25-17-10-9-16(21-22-17)14-5-3-2-4-6-14/h2-6,9-11,15H,7-8,12H2,1H3
InChi Key DPONSKCACOZTGN-UHFFFAOYSA-N
Canonical SMILES CC1=CSC(=N1)N(C2CC2)C(=O)CSC3=NN=C(C=C3)C4=CC=CC=C4
Isomeric SMILES CC1=CSC(=N1)N(C2CC2)C(=O)CSC3=NN=C(C=C3)C4=CC=CC=C4
PubChem CID 70690453
Molecular Weight 382.5

Certificates

Certificate of Analysis(COA)

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10 results found

Lot NumberCertificate TypeDateItem
H2426062Certificate of AnalysisMay 13, 2024 V288619
H2426063Certificate of AnalysisMay 13, 2024 V288619
H2426064Certificate of AnalysisMay 13, 2024 V288619
H2426065Certificate of AnalysisMay 13, 2024 V288619
H2426067Certificate of AnalysisMay 13, 2024 V288619
H2426068Certificate of AnalysisMay 13, 2024 V288619
H2426070Certificate of AnalysisMay 13, 2024 V288619
H2426071Certificate of AnalysisMay 13, 2024 V288619
H2426072Certificate of AnalysisMay 13, 2024 V288619
H2426073Certificate of AnalysisMay 13, 2024 V288619

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 19.12, Max Conc. mM: 50; Solvent:ethanol, Max Conc. mg/mL: 3.83, Max Conc. mM: 10 with gentle warming

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