Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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V288619-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $68.90 | |
V288619-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $115.90 | |
V288619-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $258.90 | |
V288619-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $416.90 | |
V288619-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $616.90 |
Potent and selective KCC2 inhibitor
Synonyms | VU0463271;N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide, N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]-acetamide, N-Cyclopropyl-N-(4-methylthiazol-2-yl)-2-(6-phenylpyridazin-3-ylthio)acetamide;N |
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Specifications & Purity | ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | VU0463271 is a potent and selective potassium-chloride cotransporter 2 (KCC2) inhibitor that displays greatly enhanced potency than its structural analogs VU0255011 (ML077) & VU0240511 (IC50 = 61, 537, and 568 nM, respectively). VU0463271 exhibits much re |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
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IUPAC Name | N-cyclopropyl-N-(4-methyl-1,3-thiazol-2-yl)-2-(6-phenylpyridazin-3-yl)sulfanylacetamide |
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INCHI | InChI=1S/C19H18N4OS2/c1-13-11-26-19(20-13)23(15-7-8-15)18(24)12-25-17-10-9-16(21-22-17)14-5-3-2-4-6-14/h2-6,9-11,15H,7-8,12H2,1H3 |
InChi Key | DPONSKCACOZTGN-UHFFFAOYSA-N |
Canonical SMILES | CC1=CSC(=N1)N(C2CC2)C(=O)CSC3=NN=C(C=C3)C4=CC=CC=C4 |
Isomeric SMILES | CC1=CSC(=N1)N(C2CC2)C(=O)CSC3=NN=C(C=C3)C4=CC=CC=C4 |
PubChem CID | 70690453 |
Molecular Weight | 382.5 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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H2426062 | Certificate of Analysis | May 13, 2024 | V288619 |
H2426063 | Certificate of Analysis | May 13, 2024 | V288619 |
H2426064 | Certificate of Analysis | May 13, 2024 | V288619 |
H2426065 | Certificate of Analysis | May 13, 2024 | V288619 |
H2426067 | Certificate of Analysis | May 13, 2024 | V288619 |
H2426068 | Certificate of Analysis | May 13, 2024 | V288619 |
H2426070 | Certificate of Analysis | May 13, 2024 | V288619 |
H2426071 | Certificate of Analysis | May 13, 2024 | V288619 |
H2426072 | Certificate of Analysis | May 13, 2024 | V288619 |
H2426073 | Certificate of Analysis | May 13, 2024 | V288619 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 19.12, Max Conc. mM: 50; Solvent:ethanol, Max Conc. mg/mL: 3.83, Max Conc. mM: 10 with gentle warming |
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