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Targets
G protein-coupled receptors (GPCRs)
Metabotropic glutamate receptors
VU 0469650 hydrochloride - ≥98%(HPLC), high purity , CAS No.1443748-47-7, Allosteric modulator of mGlu 1 receptor

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VU 0469650 hydrochloride - ≥98%(HPLC), high purity , CAS No.1443748-47-7, Allosteric modulator of mGlu 1 receptor

Moligand™
≥98%(HPLC)

CAS#: 1443748-47-7
Formula: C₂₂H₂₈N₄O.HCl
Molecular Weight: 400.94
PubChem CID: 71680759

Item Number

V288658

Grouped product items
SKU	Size	Availability	Price	Qty
V288658-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$197.90
V288658-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$826.90

Potent and selective negative allosteric modulator of mGlu1receptors

View related series

mGlu1 receptor Allosteric modulator

Basic Description

Synonyms	3-[(3R)-3-Methyl-4-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-1-piperazinyl]-2-pyridinecarbonitrile hydrochloride
Specifications & Purity	≥98%(HPLC)
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of mGlu 1 receptor

Associated Targets

GRM1 Tchem Metabotropic glutamate receptor 1 1 Activities

Discover Target: GRM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-[(3R)-4-(adamantane-1-carbonyl)-3-methylpiperazin-1-yl]pyridine-2-carbonitrile;hydrochloride
INCHI	InChI=1S/C22H28N4O.ClH/c1-15-14-25(20-3-2-4-24-19(20)13-23)5-6-26(15)21(27)22-10-16-7-17(11-22)9-18(8-16)12-22;/h2-4,15-18H,5-12,14H2,1H3;1H/t15-,16?,17?,18?,22?;/m1./s1
InChi Key	YENVAZRENOYZGQ-GUIQYPADSA-N
Canonical SMILES	CC1CN(CCN1C(=O)C23CC4CC(C2)CC(C4)C3)C5=C(N=CC=C5)C#N.Cl
Isomeric SMILES	C[C@@H]1CN(CCN1C(=O)C23CC4CC(C2)CC(C4)C3)C5=C(N=CC=C5)C#N.Cl
PubChem CID	71680759
Molecular Weight	400.94

Database links

CAS Registry No.	1443748-47-7
PubChem CID	73755207
GPCRdb Ligand	VU0469650

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 40.09, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 20.05, Max Conc. mM: 50

References

1. Lovell KM, Felts AS, Rodriguez AL, Venable DF, Cho HP, Morrison RD, Byers FW, Daniels JS, Niswender CM, Conn PJ et al.. (2013) N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: identification of VU0469650, a potent and selective tool compound with CNS exposure in rats.. Bioorg Med Chem Lett, 23 (13): (3713-8). [PMID:23727046]

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