Skip to the beginning of the images gallery

VU0810464 - 98%, high purity , CAS No.2126040-21-7, Activator of K ir3.1

Moligand™
≥98%

CAS#: 2126040-21-7
Formula: C₁₈H₂₁ClFN₃O
Molecular Weight: 349.83
PubChem CID: 146014436

Item Number

V412525

Grouped product items
SKU	Size	Availability	Price
V412525-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$93.90
V412525-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$279.90
V412525-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$429.90
V412525-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$729.90
V412525-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$979.90
V412525-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,389.90

View related series

Kir3.1 Activator

Basic Description

Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	VU0810464 is a potent and selective activator of non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK/Kir3). VU0810464 displays nanomolar potency for neuronal with EC50 of 165 nM and GIRK1/4 with EC50 of 720 nM channels with improved brain
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	ACTIVATOR
Mechanism of action	Activator of K ir3.1
Product Description	Information VU0810464 is a potent and selective activator of non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK/Kir3). VU0810464 displays nanomolar potency for neuronal with EC50 of 165 nM and GIRK1/4 with EC50 of 720 nM channels with improved brain penetration.

Associated Targets

KCNJ6 Tchem G protein-activated inward rectifier potassium channel 2 0 Activities

Discover Target: KCNJ6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNJ3 Tchem G protein-activated inward rectifier potassium channel 1 0 Activities

Discover Target: KCNJ3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-(3-chloro-4-fluorophenyl)-N-(2-cyclohexyl-5-methylpyrazol-3-yl)acetamide
INCHI	InChI=1S/C18H21ClFN3O/c1-12-9-17(23(22-12)14-5-3-2-4-6-14)21-18(24)11-13-7-8-16(20)15(19)10-13/h7-10,14H,2-6,11H2,1H3,(H,21,24)
InChi Key	HNJJARDABGKWSO-UHFFFAOYSA-N
Canonical SMILES	CC1=NN(C(=C1)NC(=O)CC2=CC(=C(C=C2)F)Cl)C3CCCCC3
Isomeric SMILES	CC1=NN(C(=C1)NC(=O)CC2=CC(=C(C=C2)F)Cl)C3CCCCC3
PubChem CID	146014436
Molecular Weight	349.83

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

12 results found

Lot Number	Certificate Type	Date	Item
B2423821	Certificate of Analysis	Jan 12, 2024	V412525
B2423822	Certificate of Analysis	Jan 12, 2024	V412525
B2423828	Certificate of Analysis	Jan 12, 2024	V412525
B2423829	Certificate of Analysis	Jan 12, 2024	V412525
B2423835	Certificate of Analysis	Jan 12, 2024	V412525
B2423836	Certificate of Analysis	Jan 12, 2024	V412525
B2423838	Certificate of Analysis	Jan 12, 2024	V412525
B2423842	Certificate of Analysis	Jan 12, 2024	V412525
B2423847	Certificate of Analysis	Jan 12, 2024	V412525
B2423849	Certificate of Analysis	Jan 12, 2024	V412525
B2423853	Certificate of Analysis	Jan 12, 2024	V412525
B2423875	Certificate of Analysis	Jan 12, 2024	V412525

Safety and Hazards(GHS)

Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P301+P312:IF SWALLOWED: call a POISON CENTER/doctor/... IF you feel unwell.

References

1. Wieting JM, Vadukoot AK, Sharma S, Abney KK, Bridges TM, Daniels JS, Morrison RD, Wickman K, Weaver CD, Hopkins CR. (2017) Discovery and Characterization of 1H-Pyrazol-5-yl-2-phenylacetamides as Novel, Non-Urea-Containing GIRK1/2 Potassium Channel Activators.. ACS Chem Neurosci, 8 (9): (1873-1879). [PMID:28697302]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.