Selective ERβreceptor agonist that displays 68-fold selectivity over ERα(EC50values are 2 and 155 nM for ERβand ERαrespectively). Displays antianxiolytic and antidepressive effectsin vivo.
Storage Temp
Store at 2-8°C
Shipped In
Wet ice
Grade
Moligand™
Action Type
AGONIST
Mechanism of action
Agonist of Estrogen receptor-α;Agonist of Estrogen receptor-β
Product Description
Product Describtion:
WAY-200070 is a potent, selective estrogen receptor-beta (ER-β) agonist (IC50 2.3 nM vs. 155 nM for ER-α) with anxiolytic-like and antidepressant-like effects.
Product Application：
WAY-200070, a selective estrogen receptor-beta (ER-β) agonist, may be used in estrogen receptor signaling research along with other ERβ agonists [diarylpropionitrile (DPN)] and antagonist to help identify and differentiate the functions of estrogen receptor-beta(s) (ER-β) involved in processes such as regulation of the physiology of the endocrine pancreas; modulation of visceral pain; and stress response. WAY-200070 may be used to help establish that an observed physiological or cell signaling response is ER-β-dependent, especially versus ERα.
1.Clipperton AE, Spinato JM, Chernets C, Pfaff DW, Choleris E. (2008) Differential effects of estrogen receptor alpha and beta specific agonists on social learning of food preferences in female mice.. Neuropsychopharmacology, 33 (10):(2362-75). [PMID:18004284]
2.Hughes ZA, Liu F, Platt BJ, Dwyer JM, Pulicicchio CM, Zhang G, Schechter LE, Rosenzweig-Lipson S, Day M. (2008) WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent.. Neuropharmacology, 54 (7):(1136-42). [PMID:18423777]
Solution Calculators
Molarity Calculator
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.
C2320787