Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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W287949-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $114.90 | |
W287949-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $183.90 | |
W287949-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $435.90 | |
W287949-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $783.90 | |
W287949-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,410.90 |
Potent, non-substrate EAAT2 inhibitor
Synonyms | WAY-213613|868359-05-1|WAY 213613|N-[4-(2-Bromo-4,5-difluorophenoxy)phenyl]-L-asparagine|WAY-213,613|8QTE6AZR4F|UNII-8QTE6AZR4F|(2S)-2-amino-3-{[4-(2-bromo-4,5-difluorophenoxy)phenyl]carbamoyl}propanoic acid|N-(4-(2-Bromo-4,5-difluorophenoxy)phenyl)-L-asp |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Potent, non-substrate inhibitor of EAAT2 (GLT-1) that displays > 44-fold selectivity over EAAT1 and EAAT3 (IC50values are 85, 3787 and 5004 nM for EAAT2, EAAT3 and EAAT1 respectively). Exhibits no activity towards ionotropic and metabotropic glutamate rec |
Storage Temp | Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of Excitatory amino acid transporter 2 |
Product Description |
WAY 213613 is a selective non-substrate inhibitor of EAAT2. It is used in the methods of treating or inhibiting onset of Huntington's disease with gene modulatory compounds.
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IUPAC Name | (2S)-2-amino-4-[4-(2-bromo-4,5-difluorophenoxy)anilino]-4-oxobutanoic acid |
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INCHI | InChI=1S/C16H13BrF2N2O4/c17-10-5-11(18)12(19)6-14(10)25-9-3-1-8(2-4-9)21-15(22)7-13(20)16(23)24/h1-6,13H,7,20H2,(H,21,22)(H,23,24)/t13-/m0/s1 |
InChi Key | BNYDDAAZMBUFRG-ZDUSSCGKSA-N |
Canonical SMILES | C1=CC(=CC=C1NC(=O)CC(C(=O)O)N)OC2=CC(=C(C=C2Br)F)F |
Isomeric SMILES | C1=CC(=CC=C1NC(=O)C[C@@H](C(=O)O)N)OC2=CC(=C(C=C2Br)F)F |
WGK Germany | 3 |
PubChem CID | 11531745 |
Molecular Weight | 415.19 |
PubChem CID | 11531745 |
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ChEMBL Ligand | CHEMBL1628669 |
CAS Registry No. | 868359-05-1 |
Wikipedia | WAY-213,613 |
RCSB PDB Ligand | GJ0, GJ0 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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F2420234 | Certificate of Analysis | Mar 09, 2024 | W287949 |
F2420235 | Certificate of Analysis | Mar 09, 2024 | W287949 |
F2420236 | Certificate of Analysis | Mar 09, 2024 | W287949 |
F2420237 | Certificate of Analysis | Mar 09, 2024 | W287949 |
F2420238 | Certificate of Analysis | Mar 09, 2024 | W287949 |
F2420239 | Certificate of Analysis | Mar 09, 2024 | W287949 |
F2420240 | Certificate of Analysis | Mar 09, 2024 | W287949 |
F2420241 | Certificate of Analysis | Mar 09, 2024 | W287949 |
F2420242 | Certificate of Analysis | Mar 09, 2024 | W287949 |
F2420243 | Certificate of Analysis | Mar 09, 2024 | W287949 |
Solubility | Solvent:1eq. NaOH, Max Conc. mg/mL: 41.51, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 41.51, Max Conc. mM: 100 |
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Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H302:Harmful if swallowed |
Precautionary Statements | P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. |
WGK Germany | 3 |
RIDADR | UN28116.1/PGIII |