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WAY 213613 - 98%, high purity , CAS No.868359-05-1, Inhibitor of Excitatory amino acid transporter 2

  • Moligand™
  • ≥98%
Item Number
W287949
Grouped product items
SKUSizeAvailabilityPrice Qty
W287949-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$114.90
W287949-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$183.90
W287949-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$435.90
W287949-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$783.90
W287949-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,410.90

Potent, non-substrate EAAT2 inhibitor

Basic Description

SynonymsWAY-213613|868359-05-1|WAY 213613|N-[4-(2-Bromo-4,5-difluorophenoxy)phenyl]-L-asparagine|WAY-213,613|8QTE6AZR4F|UNII-8QTE6AZR4F|(2S)-2-amino-3-{[4-(2-bromo-4,5-difluorophenoxy)phenyl]carbamoyl}propanoic acid|N-(4-(2-Bromo-4,5-difluorophenoxy)phenyl)-L-asp
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsPotent, non-substrate inhibitor of EAAT2 (GLT-1) that displays > 44-fold selectivity over EAAT1 and EAAT3 (IC50values are 85, 3787 and 5004 nM for EAAT2, EAAT3 and EAAT1 respectively). Exhibits no activity towards ionotropic and metabotropic glutamate rec
Storage TempStore at -20°C,Desiccated
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of Excitatory amino acid transporter 2
Product Description

WAY 213613 is a selective non-substrate inhibitor of EAAT2. It is used in the methods of treating or inhibiting onset of Huntington's disease with gene modulatory compounds.

Associated Targets

SLC1A1 Tchem Excitatory amino acid transporter 3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLC1A3 Tchem Excitatory amino acid transporter 1 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLC1A6 Tchem Excitatory amino acid transporter 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLC1A2 Tchem Excitatory amino acid transporter 2 5 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (2S)-2-amino-4-[4-(2-bromo-4,5-difluorophenoxy)anilino]-4-oxobutanoic acid
INCHI InChI=1S/C16H13BrF2N2O4/c17-10-5-11(18)12(19)6-14(10)25-9-3-1-8(2-4-9)21-15(22)7-13(20)16(23)24/h1-6,13H,7,20H2,(H,21,22)(H,23,24)/t13-/m0/s1
InChi Key BNYDDAAZMBUFRG-ZDUSSCGKSA-N
Canonical SMILES C1=CC(=CC=C1NC(=O)CC(C(=O)O)N)OC2=CC(=C(C=C2Br)F)F
Isomeric SMILES C1=CC(=CC=C1NC(=O)C[C@@H](C(=O)O)N)OC2=CC(=C(C=C2Br)F)F
WGK Germany 3
PubChem CID 11531745
Molecular Weight 415.19

Certificates

Certificate of Analysis(COA)

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10 results found

Lot NumberCertificate TypeDateItem
F2420234Certificate of AnalysisMar 09, 2024 W287949
F2420235Certificate of AnalysisMar 09, 2024 W287949
F2420236Certificate of AnalysisMar 09, 2024 W287949
F2420237Certificate of AnalysisMar 09, 2024 W287949
F2420238Certificate of AnalysisMar 09, 2024 W287949
F2420239Certificate of AnalysisMar 09, 2024 W287949
F2420240Certificate of AnalysisMar 09, 2024 W287949
F2420241Certificate of AnalysisMar 09, 2024 W287949
F2420242Certificate of AnalysisMar 09, 2024 W287949
F2420243Certificate of AnalysisMar 09, 2024 W287949

Chemical and Physical Properties

SolubilitySolvent:1eq. NaOH, Max Conc. mg/mL: 41.51, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 41.51, Max Conc. mM: 100

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H302:Harmful if swallowed

Precautionary Statements

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P317:IF SWALLOWED: Get medical help.

WGK Germany 3
RIDADR UN28116.1/PGIII

Related Documents

Solution Calculators