| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| W655501-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $440.90 |
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | WEE1-IN-3 is a potent Wee1 kinase inhibitor with an IC 50 of <10 nM. WEE1-IN-3 has anticancer activities In Vitro WEE1-IN-3 (example 1) inhibits cancer cell growth with IC 50 values of 100-1000 nM and <100 nM for SW480 cells and H23 cells, respectively.\nWEE1 kinase plays a role in the G2-M cell-cycle checkpoint arrest for ΌΝΑ repair before mitotic entry. Normal cells repair damaged DNA during GI arrest. Cancer cells often have a deficient G i-S checkpoint and depend on a functional G2-M checkpoint for DNA repair. WEE1 is overexpressed in various cancer types. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: <10 nM (Wee1 kinase) |
| Canonical SMILES | CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC5=C(C=C4)C6(CC6)CN(C5)C)O |
|---|---|
| Molecular Weight | 497.59 |
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