WHI-P154 - ≥98%, high purity , CAS No.211555-04-3, Inhibitor of epidermal growth factor receptor;Inhibitor of Janus kinase 1;Inhibitor of Janus kinase 2;Inhibitor of Janus kinase 3

Item Number

W125072

• Synonyms: WHI-P154|211555-04-3|WHI-P 154|jak3 inhibitor ii|2-Bromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol|2-bromo-4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol|2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol|PG8BT6T9MB|CHEMBL473773|4-(3'-bromo-4'-hydro
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: JAK3 inhibitor (IC50= 1.8μM) that displays no activity at JAK1 or JAK2. Inhibits STAT1 activation, iNOS expression and NO production in macrophagesin vitro. Also inhibits other common kinases including EGFR (IC50= 4 nM), Src, Abl, VEGFR, MAPK and PI 3-K a
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of epidermal growth factor receptor;Inhibitor of Janus kinase 1;Inhibitor of Janus kinase 2;Inhibitor of Janus kinase 3
• Note: 50mg卖完停产，不再备货

Product Description

WHI-P154 is a potent JAK3 inhibitor with IC50 of 1.8 μM, no activity against JAK1 or JAK2, also inhibits EGFR, Src, Abl, VEGFR and MAPK, prevents Stat3, but not Stat5 phosphorylation.
A JAK3 inhibitor which inhibits other common kinases.