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WZ8040 - ≥98%, high purity , CAS No.1214265-57-2

≥98%

CAS#: 1214265-57-2
Formula: C₂₄H₂₅ClN₆OS
Molecular Weight: 481.02
PubChem CID: 44607531

Item Number

W126471

Grouped product items
SKU	Size	Availability	Price
W126471-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$27.90
W126471-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$93.90
W126471-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$139.90
W126471-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$239.90
W126471-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$359.90
W126471-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$539.90

View related series

EGFR inhibitor

Basic Description

Synonyms	WZ8040\|1214265-57-2\|WZ-8040\|N-(3-((5-chloro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)thio)phenyl)acrylamide\|N-[3-[5-chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]sulfanylphenyl]prop-2-enamide\|WZ 8040\|SCHEMBL93523\|MLS006011280
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	WZ8040 is 30- to 100-fold more potent against EGFR T790M, and up to 100-fold less potent against wild-type EGFR, than quinazoline-based EGFR inhibitors such as CL-387785 and HKI-272. WZ8040 treatment potently inhibits the growth of HCC827 (EGFR Del E746_A
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I). A potent inhibitor of EGFR T790M

Associated Targets

BRD4 Tchem Bromodomain-containing protein 4 0 Activities

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CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

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FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

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CSNK1D Tchem Casein kinase I isoform delta 0 Activities

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TRIM24 Tchem Transcription intermediary factor 1-alpha 0 Activities

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BRPF1 Tchem Peregrin 0 Activities

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AURKA Tchem Aurora kinase A 0 Activities

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ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

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GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

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MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

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Names and Identifiers

IUPAC Name	N-[3-[5-chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]sulfanylphenyl]prop-2-enamide
INCHI	InChI=1S/C24H25ClN6OS/c1-3-22(32)27-18-5-4-6-20(15-18)33-23-21(25)16-26-24(29-23)28-17-7-9-19(10-8-17)31-13-11-30(2)12-14-31/h3-10,15-16H,1,11-14H2,2H3,(H,27,32)(H,26,28,29)
InChi Key	KIISCIGBPUVZBF-UHFFFAOYSA-N
Canonical SMILES	CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)SC4=CC=CC(=C4)NC(=O)C=C)Cl
Isomeric SMILES	CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)SC4=CC=CC(=C4)NC(=O)C=C)Cl
PubChem CID	44607531
Molecular Weight	481.02

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10 results found

Lot Number	Certificate Type	Date	Item
F2426169	Certificate of Analysis	Mar 08, 2024	W126471
F2426170	Certificate of Analysis	Mar 08, 2024	W126471
F2426171	Certificate of Analysis	Mar 08, 2024	W126471
F2426172	Certificate of Analysis	Mar 08, 2024	W126471
F2426173	Certificate of Analysis	Mar 08, 2024	W126471
F2426174	Certificate of Analysis	Mar 08, 2024	W126471
F2426175	Certificate of Analysis	Mar 08, 2024	W126471
F2426176	Certificate of Analysis	Mar 08, 2024	W126471
F2426177	Certificate of Analysis	Mar 08, 2024	W126471
F2426178	Certificate of Analysis	Mar 08, 2024	W126471

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