The store will not work correctly when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
XE-991 - 98%, high purity , CAS No.122955-42-4, Inhibitor of K v7.1;Inhibitor of K v7.2;Inhibitor of K v7.4;Inhibitor of K v7.5
a potent & selective inhibitor of KCNQ voltage-gated K-channels
Basic Description Synonyms XE 991 dihydrochloride|122955-13-9|122955-42-4|XE991Dihydrochloride|XE991 Dihydrochloride|10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE|XE991 HCl|10,10-bis(pyridin-4-ylmethyl)anthracen-9-one;dihydrochloride|10,10-bis(pyridin-4-ylmethyl) Specifications & Purity 98% Storage Temp Store at 2-8°C,Desiccated Shipped In Wet ice Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of K v7.1;Inhibitor of K v7.2;Inhibitor of K v7.4;Inhibitor of K v7.5 Product Description XE 991 dihydrochloride is a potent and selective blocker of KCNQ voltage-gated potassium channels. Blocks KCNQ2|+3|/M-currents (IC|50|= 0.6-0.98 μM) and KCNQ1 homomeric channels (IC|50|= 0.75 μM) but is less potent against KCNQ1/minK channels (IC|50|= 11.1 μM).
Names and Identifiers Pubchem Sid 488201133 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488201133 IUPAC Name 10,10-bis(pyridin-4-ylmethyl)anthracen-9-one;dihydrochloride INCHI InChI=1S/C26H20N2O.2ClH/c29-25-21-5-1-3-7-23(21)26(17-19-9-13-27-14-10-19,18-20-11-15-28-16-12-20)24-8-4-2-6-22(24)25;;/h1-16H,17-18H2;2*1H InChi Key WOGWMARIFDNZON-UHFFFAOYSA-N Canonical SMILES C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3C2(CC4=CC=NC=C4)CC5=CC=NC=C5.Cl.Cl Isomeric SMILES C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3C2(CC4=CC=NC=C4)CC5=CC=NC=C5.Cl.Cl RTECS CB1530000 PubChem CID 45073462 Molecular Weight 376.45
Chemical and Physical Properties Solubility Soluble in DMSO (12 mg/mL).
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
RTECS CB1530000
Solution Calculators Molarity Calculator Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator
C23201148