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XL228 - 10mM in DMSO, high purity , CAS No.898280-07-4

10mM in DMSO

CAS#: 898280-07-4
Formula: C₂₂H₃₁N₉O
Molecular Weight: 437.54
PubChem CID: 59757974

Item Number

X426744

Grouped product items
SKU	Size	Availability	Price	Qty
X426744-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$241.90

Basic Description

Synonyms	XL228\|XL-228\|898280-07-4\|XL 228\|4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-N-[(3-propan-2-yl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine\|Exel-2280\|33M2XSK003\|2,4-Pyrimidinediamine, N(sup 4)-(5-cyclopropyl-1H-pyrazol-3-yl)-N(sup 2)-
Specifications & Purity	10mM in DMSO
Storage Temp	Store at -80°C
Shipped In	Dry ice

Associated Targets

ERCC2 Tchem General transcription and DNA repair factor IIH helicase subunit XPD 1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EPHB6 Tchem Ephrin type-B receptor 6 1 Activities

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EPHA1 Tchem Ephrin type-A receptor 1 1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTK2 Tclin Focal adhesion kinase 1 1 Activities

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CDK17 Tchem Cyclin-dependent kinase 17 1 Activities

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RET Tclin Proto-oncogene tyrosine-protein kinase receptor Ret 1 Activities

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FYN Tclin Tyrosine-protein kinase Fyn 1 Activities

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EPHA7 Tchem Ephrin type-A receptor 7 1 Activities

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FLT3 Tclin Receptor-type tyrosine-protein kinase FLT3 1 Activities

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FGFR1 Tclin Fibroblast growth factor receptor 1 1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TNK1 Tchem Non-receptor tyrosine-protein kinase TNK1 1 Activities

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PLK4 Tchem Serine/threonine-protein kinase PLK4 1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PKN1 Tchem Serine/threonine-protein kinase N1 1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAP4K1 Tchem Mitogen-activated protein kinase kinase kinase kinase 1 1 Activities

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BMP2K Tchem BMP-2-inducible protein kinase 1 Activities

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BCR Tclin Breakpoint cluster region protein 1 Activities

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AURKA Tchem Aurora kinase A 1 Activities

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AURKB Tchem Aurora kinase B 1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Tchem Uncharacterized protein FLJ45252 1 Activities

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ACVR1 Tchem Activin receptor type-1 1 Activities

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ABL2 Tchem Tyrosine-protein kinase ABL2 1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NTRK1 Tclin High affinity nerve growth factor receptor 1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-N-[(3-propan-2-yl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine
INCHI	InChI=1S/C22H31N9O/c1-14(2)17-10-16(32-29-17)13-23-22-25-19(24-20-11-18(27-28-20)15-4-5-15)12-21(26-22)31-8-6-30(3)7-9-31/h10-12,14-15H,4-9,13H2,1-3H3,(H3,23,24,25,26,27,28)
InChi Key	ALKJNCZNEOTEMP-UHFFFAOYSA-N
Canonical SMILES	CC(C)C1=NOC(=C1)CNC2=NC(=CC(=N2)N3CCN(CC3)C)NC4=NNC(=C4)C5CC5
Isomeric SMILES	CC(C)C1=NOC(=C1)CNC2=NC(=CC(=N2)N3CCN(CC3)C)NC4=NNC(=C4)C5CC5
PubChem CID	59757974
Molecular Weight	437.54

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