XL647 , CAS No.651031-01-5, Inhibitor of EPH receptor B4;Inhibitor of epidermal growth factor receptor;Inhibitor of erb-b2 receptor tyrosine kinase 2;Inhibitor of fms related receptor tyrosine kinase 4;Inhibitor of kinase insert domain receptor

Item Number

X337831

• Synonyms: Tesevatinib|XL647|XL-647|781613-23-8|EXEL-7647|KD019|KD-019|XL 647|EXEL 7647|KD 019|KD-020|F6XM2TN5A1|N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-(((3aR,5r,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine|N-(3,4-Dichloro-2-fluorop
• Specifications & Purity: Moligand™
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of EPH receptor B4;Inhibitor of epidermal growth factor receptor;Inhibitor of erb-b2 receptor tyrosine kinase 2;Inhibitor of fms related receptor tyrosine kinase 4;Inhibitor of kinase insert domain receptor

Product Description

XL657 is an extremely potent and selective inhibitor of EGFR phosphorylation (IC50 = 0.3 nM). Inhibition of EGFR blocks signal transduction and thus impedes vascularization. Also inhibits other receptor tyrosine kinases such as Neu (ErbB2), Flk-1 (KDR), EphB4, and Flt-4.