XMD8-92 - ≥97%, high purity , CAS No.1234480-50-2, Inhibitor of doublecortin like kinase 2;Inhibitor of mitogen-activated protein kinase 7;Inhibitor of polo like kinase 4;Inhibitor of tyrosine kinase non receptor 1
XMD8-92 - ≥97%, high purity , CAS No.1234480-50-2, Inhibitor of doublecortin like kinase 2;Inhibitor of mitogen-activated protein kinase 7;Inhibitor of polo like kinase 4;Inhibitor of tyrosine kinase non receptor 1
ERK5 (BMK1) and BRD4 inhibitor (Kdvalues are 80 and 190 nM, respectively). Also inhibits DCAMKL2, PLK4 and TNK1 (Kdvalues are 190, 600 and 890 nM). Blocks growth factor-induced activation of cellular BMK1 and reduces BMK1 activity inin vitrokinase assays.
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of doublecortin like kinase 2;Inhibitor of mitogen-activated protein kinase 7;Inhibitor of polo like kinase 4;Inhibitor of tyrosine kinase non receptor 1
Product Description
XMD8-92 has been used as a specific extracellular signal regulated kinase 5 (ERK5) inhibitor in human umbilical vein endothelial cells (HUVECs) culture.
1.Yang Q, Deng X, Lu B, Cameron M, Fearns C, Patricelli MP, Yates 3rd JR, Gray NS, Lee JD. (2010) Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein.. Cancer Cell, 18 (3):(258-67). [PMID:20832753]
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K2108433