| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| X655659-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $495.90 |
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | XPC-6444 is a highly potent, isoform-selective, and CNS-penetrant Na V 1.6 inhibitor ( IC 50 =41 nM for hNa V 1.6). XPC-6444 also displays potent block of Na V 1.2 (IC 50 =125 nM). XPC-6444 shows anticonvulsant activity In Vitro XPC-6444 shows high selectivity over Na V 1.1 and Na V 1.5. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo XPC-6444 exhibits good metabolic stability in human liver microsomes and hepatocytes, and low potential for MDR1 mediated efflux . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 41 nM (hNa V 1.6), 125 nM (hNa V 1.2) |
| Canonical SMILES | O=S(C1=C(F)C=C(NCC2=C(F)C=CC=C2CN(C(C)(C)C)C)C=C1F)(NC3=CSC=N3)=O |
|---|---|
| Molecular Weight | 498.58 |
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