XR8-89 is a potent papain-like protease (PL pro ) inhibitor with an IC 50 value of 0.1 μM. XR8-89 induces conformational changes in SARS-COV-2 papain-like protease, inhibiting SARS-CoV-2 replication. XR8-89 can be used for SARS-CoV-2 research
In Vitro
XR8-89 induces conformational changes manly in BL2 region and increases the activity against PL pro. MCE has not independently confirmed the accuracy of these methods. They are for reference only.