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Y-27632 2HCl - 99%, high purity , CAS No.129830-38-2

Item Number
Y412681
Grouped product items
SKUSizeAvailabilityPrice Qty
Y412681-5mg
5mg
2
$32.90
Y412681-10mg
10mg
2
$49.90
Y412681-50mg
50mg
2
$169.90
Y412681-100mg
100mg
3
$273.90
Y412681-250mg
250mg
2
$548.90
Y412681-1g
1g
2
$1,756.90

ROCK2 Selective Inhibitors

Basic Description

SynonymsCYCLOHEXANECARBOXAMIDE, 4-((1R)-1-AMINOETHYL)-N-4-PYRIDINYL-, HYDROCHLORIDE (1:2), TRANS- | DTXSID90204535 | Y-27632 - CAS 146986-50-7 | HY-10583 | DTXSID3042635 | Unibiotic | NCGC00261018-01 | (R)-(+)-TRANS-N-(4-PYRIDYL)-4-(1-AMINOETHYL)-CYCLOHEXANECAR B
Specifications & PurityMoligand™, ≥99%
Biochemical and Physiological MechanismsY-27632 is highly potent, cell-permeable, selective ROCK (Rho-associated coiled coil forming protein serine/threonine kinase) inhibitor. Ki = 140 nM for p160ROCK. Y-27632 also inhibits ROCK-II with equal potency. The inhibition is competitive with respect
Storage TempProtected from light,Store at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Product Description

Y-27632 dihydrochloride is an effective bronchodilator and improves lung resistance (RL) induced by antigen and acetylcholine. Y-27632 controls neutrophil migration and lung edema and may be a potential agent against acute lung injury.The utilization of Y-27632 dihydrochloride, in conjunction with Accutase or other enzyme solutions, during the passaging of human embryonic stem (hES) cells has been demonstrated to enhance cell survival and significantly improve cloning efficiency.Y-27632, a Rho-kinase inhibitor, counteracts noradrenergic contractions in the penile corpus cavernosum of rabbits and humans. It helps to relax vascular and non-vascular smooth muscle in various preparations and lower blood pressure in hypertensive rats.Additionally, this inhibitor induces reversible changes in cell shape and decreases in actin stress fibers, focal adhesions, and protein phosphotyrosine staining in human trabecular meshwork (TM) cells and Schlemm′s canal cells. Y-27632 inhibits the kinase activity of both ROCK-I and ROCK-II in vitro, and this inhibition is competitively reversed by ATP, indicating that these compounds bind to the catalytic site to inhibit the kinases.[6] Ki = 140 nM for p160ROCK.

Information

Y-27632 2HCl is a selectiveROCK1 (p160ROCK)inhibitor withKiof 140 nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.

AI Insight

Names and Identifiers

Pubchem Sid504765064
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504765064
IUPAC Name 4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide;dihydrochloride
INCHI InChI=1S/C14H21N3O.2ClH/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13;;/h6-12H,2-5,15H2,1H3,(H,16,17,18);2*1H/t10-,11?,12?;;/m1../s1
InChi Key IDDDVXIUIXWAGJ-DDSAHXNVSA-N
Canonical SMILES Cl.Cl.C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)Nc2ccncc2
Isomeric SMILES C[C@H](C1CCC(CC1)C(=O)NC2=CC=NC=C2)N.Cl.Cl
WGK Germany 3
Molecular Weight 320.26

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

12 results found

Lot NumberCertificate TypeDateItem
B2520337Certificate of AnalysisJan 20, 2025 Y412681
B2520338Certificate of AnalysisJan 20, 2025 Y412681
B2520340Certificate of AnalysisJan 20, 2025 Y412681
B2520344Certificate of AnalysisJan 20, 2025 Y412681
B2520345Certificate of AnalysisJan 20, 2025 Y412681
J2430132Certificate of AnalysisNov 01, 2024 Y412681
F2223005Certificate of AnalysisApr 03, 2024 Y412681
F2223006Certificate of AnalysisApr 03, 2024 Y412681
F2223007Certificate of AnalysisApr 03, 2024 Y412681
F2223008Certificate of AnalysisApr 03, 2024 Y412681
F2223009Certificate of AnalysisApr 03, 2024 Y412681
F2223010Certificate of AnalysisApr 03, 2024 Y412681

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Chemical and Physical Properties

SolubilityDMSO;H2O(Sonication is recommended)
SensitivityLight sensitive;Heat sensitive;Moisture sensitive
Specific Rotation[α]+4.0° (C=1,MeOH)
Melt Point(°C)252 °C
Molecular Weight320.300 g/mol
XLogP3
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass319.122 Da
Monoisotopic Mass319.122 Da
Topological Polar Surface Area68.000 Ų
Heavy Atom Count20
Formal Charge0
Complexity268.000
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count3

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H302:Harmful if swallowed

H312:Harmful in contact with skin

H332:Harmful if inhaled

H302+H312+H332:Harmful if swallowed, in contact with skin or if inhaled

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P301+P317:IF SWALLOWED: Get medical help.

P317:Get emergency medical help.

WGK Germany 3

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Citations of This Product(1)

1. Fan Zhao, Luchen Sun, Nanfei Yang, Wei Zheng, Pingping Shen, Yahong Huang, Yan Lu.  (2020)  Increased release of microvesicles containing mitochondria is associated with the myeloid differentiation of AML-M5 leukaemia cells.  EXPERIMENTAL CELL RESEARCH,  395  (112213).  [PMID:32758487] [10.1016/j.yexcr.2020.112213]

References

1. Fan Zhao, Luchen Sun, Nanfei Yang, Wei Zheng, Pingping Shen, Yahong Huang, Yan Lu.  (2020)  Increased release of microvesicles containing mitochondria is associated with the myeloid differentiation of AML-M5 leukaemia cells.  EXPERIMENTAL CELL RESEARCH,  395  (112213).  [PMID:32758487] [10.1016/j.yexcr.2020.112213]

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