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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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Y125330-5mg | 5mg | In stock | $48.90 | |
Y125330-10mg | 10mg | In stock | $68.90 | |
Y125330-25mg | 25mg | In stock | $155.90 | |
Y125330-50mg | 50mg | In stock | $206.90 | |
Y125330-100mg | 100mg | In stock | $345.90 |
Synonyms | y-27632|146986-50-7|Y27632|Y 27632|cyclohexanecarboxamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, trans-|4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide|Y-27632, free base|0X370ROP6H|CHEBI:75393|4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexa |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Y-27632 is ROCK inhibitor, as a novel bronchodilator. Y-27632 is available with IC50 of 3.3±0.25 μM and 2.8±0.2 μM in human and rabbit tissues, respectively. |
Storage Temp | Protected from light,Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of protein kinase C epsilon;Inhibitor of protein kinase N2;Inhibitor of Rho associated coiled-coil containing protein kinase 1;Inhibitor of Rho associated coiled-coil containing protein kinase 2 |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | 4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide |
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INCHI | InChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11?,12?/m1/s1 |
InChi Key | IYOZTVGMEWJPKR-VOMCLLRMSA-N |
Canonical SMILES | CC(C1CCC(CC1)C(=O)NC2=CC=NC=C2)N |
Isomeric SMILES | C[C@H](C1CCC(CC1)C(=O)NC2=CC=NC=C2)N |
PubChem CID | 448042 |
Molecular Weight | 247.34 |
CAS Registry No. | 146986-50-7 |
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Wikipedia | Y-27632 |
PubChem CID | 448042 |
ChEMBL Ligand | CHEMBL559147 |
RCSB PDB Ligand | Y27 |
Enter Lot Number to search for COA:
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Lot Number | Certificate Type | Date | Item |
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J2218767 | Certificate of Analysis | Aug 15, 2024 | Y125330 |
J2218780 | Certificate of Analysis | Aug 15, 2024 | Y125330 |
J2218782 | Certificate of Analysis | Aug 15, 2024 | Y125330 |
J2218783 | Certificate of Analysis | Aug 15, 2024 | Y125330 |
J2218757 | Certificate of Analysis | Aug 14, 2024 | Y125330 |
E2415061 | Certificate of Analysis | Aug 10, 2022 | Y125330 |
Solubility | 49 mg/mL(198.11 mM) in DMSO;Insoluble in Water;49 mg/mL (198.11 mM) in Ethanol |
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Sensitivity | light sensitive |
Pictogram(s) | GHS09, GHS07 |
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Signal | Warning |
Hazard Statements | H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled H410:Very toxic to aquatic life with long lasting effects |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help. |
Starting at $241.90
1. Wu F, Büttner FH, Chen R, Hickey E, Jakes S, Kaplita P, Kashem MA, Kerr S, Kugler S, Paw Z et al.. (2010) Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account.. Bioorg Med Chem Lett, 20 (11): (3235-9). [PMID:20462760] |