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Y-27632 dihydrochloride - ≥98%, high purity , CAS No.129830-38-2

1 Citations

≥98%

CAS#: 129830-38-2
Formula: C₁₄H₂₁N₃O·2HCl
Molecular Weight: 320.26
MDL number: MFCD03490488

Item Number

Y129399

Grouped product items
SKU	Size	Availability	Price
Y129399-5mg	5mg	In stock	$29.90
Y129399-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$45.90
Y129399-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$159.90
Y129399-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$259.90
Y129399-500mg	500mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$719.90

Selective Rho kinase inhibitor

Basic Description

Synonyms	ROCK Inhibitor \| CYCLOHEXANECARBOXAMIDE, 4-((1R)-1-AMINOETHYL)-N-4-PYRIDINYL-, HYDROCHLORIDE (1:2), TRANS- \| DTXSID90204535 \| Y-27632 - CAS 146986-50-7 \| HY-10583 \| DTXSID3042635 \| Unibiotic \| NCGC00261018-01 \| (R)-(+)-TRANS-N-(4-PYRIDYL)-4-(1-AMINOETHYL)
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Y-27632 is ROCK inhibitor, as a novel bronchodilator. Y-27632 is available with IC50 of 3.3±0.25 μM and 2.8±0.2 μM in human and rabbit tissues, respectively.Y-27632 is a research tool with a wide variety of biological effects, mainly u
Legal Information	Sold under license from Mitsubishi Pharma Corporation
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Y-27632 dihydrochloride is a selective Rho-kinase inhibitor, which suppresses cholinergic nerve-mediated contractions. In addition, studies show that Y-27632 dihydrochloride increases the release of neurotransmitters from cholinergic nerves. Studies conducted on smooth muscle preparations suggest that Y-27632 dihydrochloride suppresses nerve-mediated contractile responses stimulated by acetylcholine and noradrenaline. Furthermore, studies on lung tissue damage in rats suggest that Y-27632 dihydrochloride can restore the damage caused by oleic acid by inhibition of ROCK-1 and ROCK-2. Y-27632 dihydrochloride also inhibits protein kinase C related kinase, PRK2. A cell permeable inhibitor of ROCK-1 and ROCK-2

Names and Identifiers

IUPAC Name	4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide;dihydrochloride
INCHI	InChI=1S/C14H21N3O.2ClH/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13;;/h6-12H,2-5,15H2,1H3,(H,16,17,18);2*1H/t10-,11?,12?;;/m1../s1
InChi Key	IDDDVXIUIXWAGJ-DDSAHXNVSA-N
Canonical SMILES	Cl.Cl.C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)Nc2ccncc2
Isomeric SMILES	C[C@H](C1CCC(CC1)C(=O)NC2=CC=NC=C2)N.Cl.Cl
WGK Germany	3
Molecular Weight	320.26

Certificates

Certificate of Analysis(COA)

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Find and download the COA for your product by matching the lot number on the packaging.

12 results found

Lot Number	Certificate Type	Date	Item
H2206871	Certificate of Analysis	May 11, 2024	Y129399
H2206872	Certificate of Analysis	May 11, 2024	Y129399
H2206873	Certificate of Analysis	May 11, 2024	Y129399
H2206909	Certificate of Analysis	May 11, 2024	Y129399
H2206916	Certificate of Analysis	May 11, 2024	Y129399
C2219546	Certificate of Analysis	Jan 05, 2024	Y129399
C2219547	Certificate of Analysis	Jan 05, 2024	Y129399
C2219550	Certificate of Analysis	Jan 05, 2024	Y129399
I2109462	Certificate of Analysis	Jun 15, 2023	Y129399
I2109464	Certificate of Analysis	Jun 15, 2023	Y129399
I2109465	Certificate of Analysis	Jun 15, 2023	Y129399
C2219548	Certificate of Analysis	Feb 17, 2022	Y129399

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Chemical and Physical Properties

Solubility	Soluble in water (14 mg/mL), ethanol (~5 mg/mL), DMSO (~20 mg/mL), DMF (~30 mg/mL), PBS, pH 7.2 (~10 mg/mL), and methanol (25 mg/mL).
Sensitivity	Light sensitive ；Heat sensitive ；Moisture sensitive
Specific Rotation[α]	+4.0° (C=1,MeOH)
Melt Point(°C)	252 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled H302+H312+H332:Harmful if swallowed, in contact with skin or if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help.
WGK Germany	3

FAQs and Articles

FAQ

Neurotransmitters, Receptors, and Transporters

Categories: Technical articles

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inhibitor Neurons neurotransmission

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Fan Zhao, Luchen Sun, Nanfei Yang, Wei Zheng, Pingping Shen, Yahong Huang, Yan Lu. (2020) Increased release of microvesicles containing mitochondria is associated with the myeloid differentiation of AML-M5 leukaemia cells. EXPERIMENTAL CELL RESEARCH, 395 (112213). [PMID:32758487] [10.1016/j.yexcr.2020.112213]

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Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.