JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

Click Here for 5% Off Your First Aladdin Purchase!

྾

Home
Applications
Targets
Kinases
CMGC:Containing CDK, MAPK, GSK3, CLK families
YL5084 , CAS No.Y614917, Inhibitor of mitogen-activated protein kinase 8;Inhibitor of mitogen-activated protein kinase 9

Skip to the end of the images gallery

Skip to the beginning of the images gallery

YL5084 , CAS No.Y614917, Inhibitor of mitogen-activated protein kinase 8;Inhibitor of mitogen-activated protein kinase 9

Moligand™

PubChem CID: 153610906

Item Number

Y614917

Grouped product items
SKU	Size	Availability	Price	Qty
Y614917-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$560.90
Y614917-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,500.90

View related series

mitogen-activated protein kinase 8 Inhibitor mitogen-activated protein kinase 9 Inhibitor

Basic Description

Synonyms	YL-5084
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of mitogen-activated protein kinase 8;Inhibitor of mitogen-activated protein kinase 9

Associated Targets

MAPK8 Tchem Mitogen-activated protein kinase 8 0 Activities

Discover Target: MAPK8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK9 Tchem Mitogen-activated protein kinase 9 0 Activities

Discover Target: MAPK9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(E)-4-(dimethylamino)-N-[4-[(3S,4S)-3-methyl-4-[[4-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-yl]amino]pyrrolidine-1-carbonyl]phenyl]but-2-enamide
INCHI	InChI=1S/C35H36N8O2/c1-24-22-42(34(45)26-14-16-27(17-15-26)37-31(44)13-9-20-41(2)3)23-29(24)39-35-36-19-18-28(38-35)32-30-12-7-8-21-43(30)40-33(32)25-10-5-4-6-11-25/h4-19,21,24,29H,20,22-23H2,1-3H3,(H,37,44)(H,36,38,39)/b13-9+/t24-,29+/m0/s1
InChi Key	FVONQZQMUHLATI-PIAHHGHBSA-N
Canonical SMILES	C[C@H]1CN(C(C2=CC=C(C=C2)NC(/C=C/CN(C)C)=O)=O)C[C@H]1NC3=NC=CC(C4=C5C=CC=CN5N=C4C6=CC=CC=C6)=N3
PubChem CID	153610906

Database links

PubChem CID	153610906

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

References

1. Lu W, Liu Y, Gao Y, Geng Q, Gurbani D, Li L, Ficarro SB, Meyer CJ, Sinha D, You I et al.. (2023) Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1.. J Med Chem, 66 (5): (3356-3371). [PMID:36826833]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.