| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| E656358-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $275.90 |
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Store at -80°C |
| Shipped In | Dry ice |
| Product Description | (Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor of eIF4E/eIF4G interaction and of translation initiation . (Z)-4EGI-1 effectively binds to eIF4E with an IC 50 of 43.5 μM and a K d value of 8.74 μM. (Z)-4EGI-1 has anticancer activity In Vitro (Z)-4EGI-1 (15-30 µM; 6 hours; CRL-2813 melanoma cells) treatment markedly reduces the expressions of the regulatory proteins: cyclin D1, cyclin E, and Survivin, while the expressions of housekeeping proteins such as β-Actin and α-Tubulin are not affected. (Z)-4EGI-1 inhibits cancer cells proliferation with IC 50 values of 15.3 μM and 11.6 μM for CRL-2351 breast cells and CRL-2813 melanoma cells, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: CRL-2813 melanoma cells Concentration: 15 µM, 30 µM Incubation Time: 6 hours Result: Markedly reduced the expressions of the regulatory proteins: cyclin D1, cyclin E, and Survivin. IC50& Target:eIF4 |
| Canonical SMILES | O=C(O)/C(CC1=CC=CC=C1[N+]([O-])=O)=N/NC2=NC(C3=CC=C(Cl)C(Cl)=C3)=CS2 |
|---|---|
| Molecular Weight | 451.28 |
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