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ZAK inhibitor 6p , CAS No.Z614939, Inhibitor of ABL proto-oncogene 1; non-receptor tyrosine kinase;Inhibitor of BLK proto-oncogene; Src family tyrosine kinase;Inhibitor of LCK proto-oncogene; Src family tyrosine kinase;Inhibitor of LIM domain kinase 1;Inhibitor of LIM domain kinase 2;Inhib

Moligand™

PubChem CID: 138393294

Item Number

Z614939

Grouped product items
SKU	Size	Availability	Price	Qty
Z614939-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
Z614939-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

ABL proto-oncogene 1，non-receptor tyrosine kinase Inhibitor BLK proto-oncogene，Src family tyrosine kinase Inhibitor LCK proto-oncogene，Src family tyrosine kinase Inhibitor LIM domain kinase 1 Inhibitor LIM domain kinase 2 Inhibitor receptor interacting serine/threonine kinase 2 Inhibitor ZAK sterile alpha motif and leucine zipper containing kinase AZK Inhibitor

Basic Description

Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of ABL proto-oncogene 1; non-receptor tyrosine kinase;Inhibitor of BLK proto-oncogene; Src family tyrosine kinase;Inhibitor of LCK proto-oncogene; Src family tyrosine kinase;Inhibitor of LIM domain kinase 1;Inhibitor of LIM domain kinase 2;Inhib

Associated Targets

FLT3 Tclin Receptor-type tyrosine-protein kinase FLT3 0 Activities

Discover Target: FLT3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RIPK2 Tchem Receptor-interacting serine/threonine-protein kinase 2 0 Activities

Discover Target: RIPK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LIMK1 Tchem LIM domain kinase 1 1 Activities

Discover Target: LIMK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LCK Tclin Tyrosine-protein kinase Lck 0 Activities

Discover Target: LCK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LIMK2 Tchem LIM domain kinase 2 0 Activities

Discover Target: LIMK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRAF Tclin Serine/threonine-protein kinase B-raf 0 Activities

Discover Target: BRAF

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BLK Tchem Tyrosine-protein kinase Blk 0 Activities

Discover Target: BLK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABL1 Tclin Tyrosine-protein kinase ABL1 1 Activities

Discover Target: ABL1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAP3K20 Tchem Mitogen-activated protein kinase kinase kinase 20 3 Activities

Discover Target: MAP3K20

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-(2,4-Difluoro-3-(4-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-1H-1,2,3-triazol-1-yl)phenyl)-[1,1'-biphenyl]-3-sulfonamide
INCHI	InChI=1S/C27H19F2N7O3S/c1-39-27-20-13-18(14-30-26(20)32-33-27)23-15-36(35-31-23)25-21(28)10-11-22(24(25)29)34-40(37,38)19-9-5-8-17(12-19)16-6-3-2-4-7-16/h2-15,34H,1H3,(H,30,32,33)
InChi Key	QRDCOOSKIFYKIQ-UHFFFAOYSA-N
Canonical SMILES	COc1n[nH]c2c1cc(cn2)c1nnn(c1)c1c(F)ccc(c1F)NS(=O)(=O)c1cccc(c1)c1ccccc1
Isomeric SMILES	COC1=NNC2=C1C=C(C=N2)C3=CN(N=N3)C4=C(C=CC(=C4F)NS(=O)(=O)C5=CC=CC(=C5)C6=CC=CC=C6)F
PubChem CID	138393294

References

1. Yang J, Shibu MA, Kong L, Luo J, BadrealamKhan F, Huang Y, Tu ZC, Yun CH, Huang CY, Ding K et al.. (2020) Design, Synthesis, and Structure-Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors.. J Med Chem, 63 (5): (2114-2130). [PMID:31244114]

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