Zansecimab (anti-ANGPT2) is an immunoglobulin G4-kappa, a monoclonal antibody against angiopoietin 2 (Ang 2). Zansecimab (anti-ANGPT2) has potential applications in angiogenesis and immune regulation.
Product Properties
Isotype
Human IgG4SP
Light Chain Type
kappa
SDS-PAGE
145.24 kDa
Purification Method
Protein A purified
Purity
>95%
Form
Liquid
Concentration
Lot by Lot
Storage Temp
Store at -80°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS
2415205-37-5
Images
Zansecimab (anti-ANGPT2) (Ab175707) - SEC The purity of Zansecimab (anti-ANGPT2) (Ab175707) is more than 95% verified by HPLC.
Zansecimab (anti-ANGPT2) (Ab175707) - ELISA Immobilized hANGPT2-chis at 2.0 μg/mL can bind Zansecimab (anti-ANGPT2) (Ab175707) with the EC₅₀ of 14.91 ng/mL.
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2.Maisonpierre, P C PC and 13 more authors.. (1997) Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.. Science (New York, N.Y.), (4):[PMID:9204896]
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5.Fiedler, Ulrike U and 8 more authors.. (2003) Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats.. The Journal of biological chemistry, (17):[PMID:12427764]
6.Lee, Hyuek Jong HJ and 9 more authors.. (2004) Biological characterization of angiopoietin-3 and angiopoietin-4.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, [PMID:15284220]
7.Barton, William A WA, Tzvetkova, Dorothea D and Nikolov, Dimitar B DB.. (2005) Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition.. Structure (London, England : 1993), [PMID:15893672]
8.Nusbaum, Chad C and 75 more authors.. (2006) DNA sequence and analysis of human chromosome 8.. Nature, (19):[PMID:16421571]
9.Barton, William A WA and 6 more authors.. (2006) Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex.. Nature structural & molecular biology, [PMID:16732286]
10.Yacyshyn, Orisha K OK and 5 more authors.. (2009) Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells.. Angiogenesis, [PMID:19116766]
11.Yuan, Hai Tao HT, Khankin, Eliyahu V EV, Karumanchi, S Ananth SA and Parikh, Samir M SM.. (2009) Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium.. Molecular and cellular biology, [PMID:19223473]
12.Leppänen, Veli-Matti and 20 more authors.. (2020) Characterization of ANGPT2 mutations associated with primary lymphedema.. Science translational medicine, (9):[PMID:32908006]
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