zapnometinib , CAS No.303175-44-2, Inhibitor of mitogen-activated protein kinase kinase 1

Item Number

Z614944

Grouped product items
SKU	Size	Availability	Price	Qty
Z614944-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
Z614944-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

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Basic Description

Synonyms	zapnometinib\|303175-44-2\|2-(2-chloro-4-iodophenylamino)-3,4-difluorobenzoic acid\|Zapnometinib [INN]\|PD-0184264\|ATR-002\|4RZD8LK83V\|Benzoic acid, 2-[(2-chloro-4-iodophenyl)amino]-3,4-difluoro-\|UNII-4RZD8LK83V\|2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic a
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of mitogen-activated protein kinase kinase 1

Names and Identifiers

IUPAC Name	2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid
INCHI	InChI=1S/C13H7ClF2INO2/c14-8-5-6(17)1-4-10(8)18-12-7(13(19)20)2-3-9(15)11(12)16/h1-5,18H,(H,19,20)
InChi Key	XCNBGWKQXRQKSA-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=C(C=C1I)Cl)NC2=C(C=CC(=C2F)F)C(=O)O
Isomeric SMILES	C1=CC(=C(C=C1I)Cl)NC2=C(C=CC(=C2F)F)C(=O)O
PubChem CID	10112191
Molecular Weight	409.55

PubChem CID

CAS Registry No.

ChEMBL Ligand

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

References

1. Tecle H, Shao J, Li Y, Kothe M, Kazmirski S, Penzotti J, Ding YH, Ohren J, Moshinsky D, Coli R et al.. (2009) Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK?. Bioorg Med Chem Lett, 19 (1): (226-9). [PMID:19019675]

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Basic Description