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ZD7288 - ≥98%, high purity , CAS No.133059-99-1

≥98%

CAS#: 133059-99-1
Formula: C₁₅H₂₁N₄ •Cl
Molecular Weight: 292.81
PubChem CID: 123983
PubChem SID: 488187782

Item Number

Z274826

Grouped product items
SKU	Size	Availability	Price
Z274826-5mg	5mg	In stock	$59.90
Z274826-10mg	10mg	In stock	$106.90
Z274826-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$478.90
Z274826-100mg	100mg	Available within 1-2 weeks(?) Item is derived from our semi-finished stock and is processed in 1-2 weeks.	$837.90

Discover ZD7288 by Aladdin Scientific in ≥98% for only $59.90. Available - in Ligands at Aladdin Scientific. Sino-atrial node function modulator Tags: .

Basic Description

Synonyms	BZ162628 \| HB1152 \| N-Ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-4-pyrimidinamine monohydrochloride \| ZD 7288 \| AS-80257 \| N-ethyl-1,2-dimethyl-6-methylimino-N-phenylpyrimidin-4-amine;hydrochloride \| J-006297 \| 4-Pyrimidinamine, N-ethyl-1,6-d
Specifications & Purity	≥98%
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads

Names and Identifiers

Pubchem Sid	488187782
IUPAC Name	N-ethyl-1,2-dimethyl-6-methylimino-N-phenylpyrimidin-4-amine;hydrochloride
INCHI	InChI=1S/C15H20N4.ClH/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15;/h6-11H,5H2,1-4H3;1H
InChi Key	DUWKUHWHTPRMAP-UHFFFAOYSA-N
Canonical SMILES	CCN(C1=CC=CC=C1)C2=CC(=NC)N(C(=N2)C)C.Cl
Isomeric SMILES	CCN(C1=CC=CC=C1)C2=CC(=NC)N(C(=N2)C)C.Cl
PubChem CID	123983
Molecular Weight	292.81

Certificates

Certificate of Analysis(COA)

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8 results found

Lot Number	Certificate Type	Date	Item
D2306498	Certificate of Analysis	Jan 15, 2024	Z274826
D2306353	Certificate of Analysis	Jan 15, 2024	Z274826
D2306430	Certificate of Analysis	Jan 12, 2024	Z274826
D2306491	Certificate of Analysis	Jan 12, 2024	Z274826
D2306600	Certificate of Analysis	Jan 12, 2024	Z274826
J2113204	Certificate of Analysis	May 11, 2023	Z274826
J2113225	Certificate of Analysis	May 11, 2023	Z274826
D2306559	Certificate of Analysis	Feb 16, 2023	Z274826

Solubility

Soluble in water to 100 mM

Sensitivity

Moisture sensitive

References

1. Lewis AS, Vaidya SP, Blaiss CA, Liu Z, Stoub TR, Brager DH, Chen X, Bender RA, Estep CM, Popov AB et al.. (2011) Deletion of the hyperpolarization-activated cyclic nucleotide-gated channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes antidepressant behavior in mice.. J Neurosci, 31 (20): (7424-40). [PMID:21593326]
2. Wei XP et al.. (2022) A novel reticular node in the brainstem synchronizes neonatal mouse crying with breathing.. Neuron, 110 (4): (644-657.e6). [PMID:34998469]
3. Clemens AM & Johnston D. (2014) Age- and location-dependent differences in store depletion-induced h-channel plasticity in hippocampal pyramidal neurons.. J Neurophysiol, 111 (6): (1369-82). [PMID:24381027]
4. Dasgupta D & Sikdar SK. (2015) Calcium permeable AMPA receptor-dependent long lasting plasticity of intrinsic excitability in fast spiking interneurons of the dentate gyrus decreases inhibition in the granule cell layer.. Hippocampus, 25 (3): (269-85). [PMID:25252134]
5. Rinke I et al.. (2010) ClC-2 voltage-gated channels constitute part of the background conductance and assist chloride extrusion.. J Neurosci, 30 (13): (4776-86). [PMID:20357128]
6. Mishra P & Narayanan R. (2022) Conjunctive changes in multiple ion channels mediate activity-dependent intrinsic plasticity in hippocampal granule cells.. iScience, 25 (3): (103922). [PMID:35252816]
7. Sparks DW & Chapman CA. (2014) Contribution of Ih to the relative facilitation of synaptic responses induced by carbachol in the entorhinal cortex during repetitive stimulation of the parasubiculum.. Neuroscience, 278 (81-92). [PMID:25130557]
8. Yang H & Xu-Friedman MA. (2010) Developmental mechanisms for suppressing the effects of delayed release at the endbulb of Held.. J Neurosci, 30 (34): (11466-75). [PMID:20739568]
9. Picton LD et al.. (2018) Control of Xenopus Tadpole Locomotion via Selective Expression of Ih in Excitatory Interneurons.. Curr Biol, 28 (24): (3911-3923.e2). [PMID:30503615]
10. Anderson TR et al.. (2010) Differential effects of Na+-K+ ATPase blockade on cortical layer V neurons.. J Physiol, 588 (Pt 22): (4401-14). [PMID:20819946]
11. Fei F et al.. (2022) Discrete subicular circuits control generalization of hippocampal seizures.. Nat Commun, 13 (5010). [PMID:36008421]
12. Cichy A et al.. (2015) Extracellular pH regulates excitability of vomeronasal sensory neurons.. J Neurosci, 35 (9): (4025-39). [PMID:25740530]
13. Kullmann PH et al.. (2016) HCN hyperpolarization-activated cation channels strengthen virtual nicotinic EPSPs and thereby elevate synaptic amplification in rat sympathetic neurons.. J Neurophysiol, 116 (2): (438-47). [PMID:27146984]
14. Putrenko I & Schwarz SK. (2011) Lidocaine blocks the hyperpolarization-activated mixed cation current, I(h), in rat thalamocortical neurons.. Anesthesiology, 115 (4): (822-35). [PMID:21832940]
15. Huang Z et al.. (2009) Loss of dendritic HCN1 subunits enhances cortical excitability and epileptogenesis.. J Neurosci, 29 (35): (10979-88). [PMID:19726656]
16. Glasgow SD & Chapman CA. (2013) Muscarinic Depolarization of Layer II Neurons of the Parasubiculum.. PLoS One, 8 (3): (e58901). [PMID:23520542]
17. Kim CS et al.. (2018) Perisomatic changes in h-channels regulate depressive behaviors following chronic unpredictable stress.. Mol Psychiatry, 23 (4): (892-903). [PMID:28416809]
18. Yamada-Hanff J & Bean BP. (2013) Persistent sodium current drives conditional pacemaking in CA1 pyramidal neurons under muscarinic stimulation.. J Neurosci, 33 (38): (15011-21). [PMID:24048831]
19. Zhang J et al.. (2021) Severe deficiency of the voltage-gated sodium channel NaV1.2 elevates neuronal excitability in adult mice.. Cell Rep, 36 (5): (109495). [PMID:34348148]
20. Cerina M et al.. (2015) Thalamic Kv 7 channels: pharmacological properties and activity control during noxious signal processing.. Br J Pharmacol, 172 (12): (3126-40). [PMID:25684311]
21. Huang Z et al.. (2012) TRIP8b-independent trafficking and plasticity of adult cortical presynaptic HCN1 channels.. J Neurosci, 32 (42): (14835-48). [PMID:23077068]
22. Garden DL et al.. (2008) Tuning of synaptic integration in the medial entorhinal cortex to the organization of grid cell firing fields.. Neuron, 60 (5): (875-89). [PMID:19081381]
23. Young CC et al.. (2009) Upregulation of inward rectifier K+ (Kir2) channels in dentate gyrus granule cells in temporal lobe epilepsy.. J Physiol, 587 (Pt 17): (4213-33). [PMID:19564397]

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