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zilurgisertib , CAS No.2173389-57-4, Inhibitor of activin A receptor type 1;Inhibitor of activin A receptor type IL;Inhibitor of bone morphogenetic protein receptor type IA;Inhibitor of bone morphogenetic protein receptor type IB;Inhibitor of transforming growth factor beta receptor 1

Moligand™

CAS#: 2173389-57-4
PubChem CID: 138628908

Item Number

Z614967

Grouped product items
SKU	Size	Availability	Price	Qty
Z614967-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
Z614967-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,390.90

View related series

activin A receptor type 1 Inhibitor activin A receptor type IL Inhibitor bone morphogenetic protein receptor type IA Inhibitor bone morphogenetic protein receptor type IB Inhibitor transforming growth factor beta receptor 1 Inhibitor

Basic Description

Synonyms	Zilurgisertib\|Zilurgisertib [INN]\|L5Z9S25HO2\|2173389-57-4\|UNII-L5Z9S25HO2\|2-Amino-N-(4-hydroxybicyclo(2.2.2)octan-1-yl)-5-(4-((1R,5S)-3-(tetrahydro-2H-pyran-4-yl)-3-azabicyclo(3.1.0)hexan-1-yl)phenyl)nicotinamide\|3-Pyridinecarboxamide, 2-amino-N-(4-hydrox
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of activin A receptor type 1;Inhibitor of activin A receptor type IL;Inhibitor of bone morphogenetic protein receptor type IA;Inhibitor of bone morphogenetic protein receptor type IB;Inhibitor of transforming growth factor beta receptor 1

Associated Targets

TGFBR1 Tchem TGF-beta receptor type-1 0 Activities

Discover Target: TGFBR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BMPR1B Tchem Bone morphogenetic protein receptor type-1B 0 Activities

Discover Target: BMPR1B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BMPR1A Tchem Bone morphogenetic protein receptor type-1A 0 Activities

Discover Target: BMPR1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACVR1 Tchem Activin receptor type-1 0 Activities

Discover Target: ACVR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACVRL1 Tchem Serine/threonine-protein kinase receptor R3 0 Activities

Discover Target: ACVRL1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-amino-N-(4-hydroxy-1-bicyclo[2.2.2]octanyl)-5-[4-[(1R,5S)-3-(oxan-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl]phenyl]pyridine-3-carboxamide
INCHI	InChI=1S/C30H38N4O3/c31-26-25(27(35)33-28-7-10-29(36,11-8-28)12-9-28)15-21(17-32-26)20-1-3-22(4-2-20)30-16-23(30)18-34(19-30)24-5-13-37-14-6-24/h1-4,15,17,23-24,36H,5-14,16,18-19H2,(H2,31,32)(H,33,35)/t23-,28?,29?,30+/m1/s1
InChi Key	KPRPFTOLWQQUAV-OCVAFRRMSA-N
Canonical SMILES	Nc1ncc(cc1C(=O)NC12CCC(CC1)(CC2)O)c1ccc(cc1)[C@]12CN(C[C@H]1C2)C1CCOCC1
Isomeric SMILES	C1COCCC1N2C[C@H]3C[C@]3(C2)C4=CC=C(C=C4)C5=CC(=C(N=C5)N)C(=O)NC67CCC(CC6)(CC7)O
PubChem CID	138628908

CAS Registry No.

2173389-57-4

PubChem CID

138628908

BindingDB Ligand

451802

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