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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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Z333288-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $266.90 |
an active free sulfhydryl compound of Zenopril
Synonyms | Zofenoprilat|75176-37-3|Zofenoprilate|Zofenoprilatum|Zofenoprilat [INN]|4G4WDK2YBS|CHEMBL16332|L-PROLINE, 1-[(2S)-3-MERCAPTO-2-METHYL-1-OXOPROPYL]-4-(PHENYLTHIO)-, 4S|(2S,4S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]-4-phenylsulfanylpyrrolidine-2-carboxylic a |
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Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of Angiotensin-converting enzyme |
Product Description | Zofenoprilat is the active free sulfhydryl compound of Zenopril. Zenopril is an antioxidant that acts as an angiotensin-converting enzyme inhibitor. Endothelial membrane studies have demonstrated that Zofenoprilat induces the bradykinin B1 receptors, which activates the expression of FGF-2. Studies show that Zofenoprilat is more effective than Enalaprilat at protecting pancreatic islets from extended high glucose exposure. We provide the Zofenoprilat Sodium Salt form. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | (2S,4S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]-4-phenylsulfanylpyrrolidine-2-carboxylic acid |
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INCHI | InChI=1S/C15H19NO3S2/c1-10(9-20)14(17)16-8-12(7-13(16)15(18)19)21-11-5-3-2-4-6-11/h2-6,10,12-13,20H,7-9H2,1H3,(H,18,19)/t10-,12+,13+/m1/s1 |
InChi Key | UQWLOWFDKAFKAP-WXHSDQCUSA-N |
Canonical SMILES | CC(CS)C(=O)N1CC(CC1C(=O)O)SC2=CC=CC=C2 |
Isomeric SMILES | C[C@H](CS)C(=O)N1C[C@H](C[C@H]1C(=O)O)SC2=CC=CC=C2 |
PubChem CID | 3034048 |
Molecular Weight | 347.43 |
DrugBank Ligand | DB08766 |
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PubChem CID | 3034048 |
ChEMBL Ligand | CHEMBL16332 |
CAS Registry No. | 75176-37-3 |
Wikipedia | Zofenoprilat |
RCSB PDB Ligand | ZED |
Reactome Reaction | R-HSA-9614933, R-HSA-9619034 |
Reactome Drug | R-ALL-9614922, R-ALL-9619042 |
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Solubility | Soluble in DMSO, water, and methanol. |
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